Lee S Y, Wolfe R A
Department of Applied Statistics, Sejong University, Seoul, Korea.
Biometrics. 1998 Sep;54(3):1176-82.
A simple method for testing the assumption of independent censoring is developed using a Cox proportional hazards regression model with a time-dependent covariate. This method involves further follow-up of a subset of lost-to-follow-up censored subjects. An adjusted estimator of the survivor function is obtained for the dependent censoring model under a proportional hazards alternative. The proposed procedure is applied to an example of a clinical trial for lung cancer and a simulation study is given for investigating the power of the proposed test.
利用带有时间相依协变量的Cox比例风险回归模型,开发了一种检验独立删失假设的简单方法。该方法涉及对一部分失访删失受试者进行进一步随访。在比例风险备择假设下,为相依删失模型获得了生存函数的调整估计量。将所提出的程序应用于一项肺癌临床试验的实例,并给出了一项模拟研究以考察所提检验的功效。