Kirii Y, Matsukura T
New Drug Discovery Research Laboratory, Kanebo LTD., Osaka, Japan.
Virus Genes. 1998;17(2):117-21. doi: 10.1023/a:1008002905588.
The complete nucleotide sequence of human papillomavirus type 67 (HPV 67) cloned from a vaginal intraepithelial neoplasia, has been determined. It consists of 7801 nucleotides with a GC content of 38.4% and exhibits similar genome organizations of genital HPVs. By phylogenetic analysis based on the full nucleotide sequences of E6 open reading frame of 28 genital HPVs, HPV 67 was clustered with HPV 16, 31, 33, 34, 35, 52, and 58.
从阴道上皮内瘤变中克隆出的人乳头瘤病毒67型(HPV 67)的完整核苷酸序列已被确定。它由7801个核苷酸组成,GC含量为38.4%,并呈现出与生殖道HPV相似的基因组结构。通过基于28种生殖道HPV的E6开放阅读框的完整核苷酸序列进行的系统发育分析,HPV 67与HPV 16、31、33、34、35、52和58聚类在一起。