情绪计数斯特鲁普范式：前扣带回情感区的功能磁共振成像探测法
The emotional counting Stroop paradigm: a functional magnetic resonance imaging probe of the anterior cingulate affective division.
作者信息
Whalen P J, Bush G, McNally R J, Wilhelm S, McInerney S C, Jenike M A, Rauch S L
机构信息
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Biol Psychiatry. 1998 Dec 15;44(12):1219-28. doi: 10.1016/s0006-3223(98)00251-0.
BACKGROUND
The emotional counting Stroop (ecStroop) functional magnetic resonance imaging (fMRI) activation paradigm was designed to recruit the anterior cingulate affective division (ACad).
METHODS
Nine normal, healthy male and female subjects (mean age 24.2 years) reported via button press the number of neutral and negative words that appeared on a screen while reaction time and fMRI data were acquired.
RESULTS
We observed a) greater ACad activation for negative versus neutral words during initial presentation blocks; b) lower overall ACad signal intensity during task performance (i.e., both negative and neutral words) compared to the baseline fixation condition; and c) no reaction time increase to negative versus neutral words.
CONCLUSIONS
In a companion study of a cognitive version of the counting Stroop (Bush et al 1998), these same 9 subjects a) activated the more dorsal anterior cingulate cognitive division; b) also showed the overall decrease in ACad signal intensity; and c) demonstrated a reliable reaction time effect. Taken together, these data offer a within-group spatial dissociation of AC function based upon information content (i.e., cognitive vs. emotional) and/or presence of behavioral interference. We propose that the ecStroop will be a useful fMRI probe of ACad function in anxiety disorders.
背景
情绪计数斯特鲁普（ecStroop）功能磁共振成像（fMRI）激活范式旨在激活前扣带回情感区（ACad）。
方法
9名正常、健康的男性和女性受试者（平均年龄24.2岁）在屏幕上出现中性和负面词汇时，通过按键报告词汇数量，同时记录反应时间和fMRI数据。
结果
我们观察到：a）在最初呈现阶段，与中性词汇相比，负面词汇引起ACad激活增强；b）与基线固定状态相比，任务执行期间（即负面和中性词汇）ACad总体信号强度降低；c）负面词汇与中性词汇相比，反应时间未增加。
结论
在计数斯特鲁普认知版本的一项配套研究中（Bush等人，1998年），同样这9名受试者：a）激活了更靠背侧的前扣带回认知区；b）同样显示出ACad信号强度总体下降；c）表现出可靠的反应时间效应。综合来看，这些数据基于信息内容（即认知与情感）和/或行为干扰的存在，提供了AC功能在组内的空间分离。我们提出，ecStroop将成为焦虑症中ACad功能的一种有用的fMRI探测工具。
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