Gupta A K, Filonenko N, Salansky N, Sauder D N
Department of Medicine, University of Toronto, Ontario, Canada.
Dermatol Surg. 1998 Dec;24(12):1383-6. doi: 10.1111/j.1524-4725.1998.tb00019.x.
Venous ulcers are estimated to be present in 0.2 to 0.4% of the population. Although new therapies have significant promise, nonhealing ulcers still represent a significant problem.
To evaluate the efficacy of low energy photon therapy (LEPT) in the treatment of venous leg ulcers.
A placebo-controlled, double-blind study using low energy photon therapy was performed in nine patients with 12 venous ulcers. Treatment was given three times a week for 10 weeks, using two monochromatic optical sources. One source provided a wavelength (lambda) of 660 nm (red) while the second source delivered a wavelength of 880 nm (infrared). Two optical probes were used, one consisted of an array of 22 monochromatic sources, operating at a wavelength of 660 nm and covering an area 6 x 10 cm2. The second probe had seven infrared sources, operating at a wavelength of 880 nm and covering an area of 4 cm2. The above configuration of optical probes was selected to cover the majority of the ulcer area being treated. The patients who were randomized to placebo treatment received sham therapy from an identical-appearing light source from the same delivery system.
Nine patients with 12 venous ulcers were randomized to receive LEPT or placebo therapy. At the conclusion of the study, the percentage of the initial ulcer area remaining unhealed in the LEPT and placebo groups was 24.4% and 84.7%, respectively (P = 0.0008). The decrease in ulcer area (compared to baseline) observed in the LEPT and placebo groups was 193.0 mm2 and 14.7 mm2, respectively (P = 0.0002). One patient dropped out of the study, complaining of lack of treatment efficacy; he was found to be randomized to the placebo group. There were no adverse effects.
In this placebo-controlled, double-blind study LEPT was an effective modality for the treatment of venous leg ulcers.
据估计，静脉性溃疡在人群中的发病率为0.2%至0.4%。尽管新疗法前景广阔，但不愈合的溃疡仍是一个重大问题。
评估低能量光子疗法（LEPT）治疗下肢静脉溃疡的疗效。
对9例患有12处静脉溃疡的患者进行了一项使用低能量光子疗法的安慰剂对照双盲研究。使用两个单色光源，每周治疗3次，共治疗10周。一个光源提供波长（λ）为660纳米（红色）的光，而第二个光源发出波长为880纳米（红外线）的光。使用了两个光学探头，一个由22个单色光源组成的阵列，工作波长为660纳米，覆盖面积为6×10平方厘米。第二个探头有7个红外线光源，工作波长为880纳米，覆盖面积为4平方厘米。选择上述光学探头配置以覆盖大部分正在治疗的溃疡区域。随机接受安慰剂治疗的患者从同一输送系统中外观相同的光源接受假治疗。
9例患有12处静脉溃疡的患者被随机分配接受LEPT或安慰剂治疗。在研究结束时，LEPT组和安慰剂组中未愈合的初始溃疡面积百分比分别为24.4%和84.7%（P = 0.0008）。LEPT组和安慰剂组观察到的溃疡面积减少（与基线相比）分别为193.0平方毫米和14.7平方毫米（P = 0.0002）。一名患者因抱怨治疗无效而退出研究；发现他被随机分配到安慰剂组。未出现不良反应。
在这项安慰剂对照双盲研究中，LEPT是治疗下肢静脉溃疡的有效方法。
