Rampling R, Symonds P
Beatson Oncology Centre, Western Infirmary, Glasgow, UK.
Curr Opin Neurol. 1998 Dec;11(6):627-32. doi: 10.1097/00019052-199812000-00003.
Radiation myelitis has long been recognised as a sinister consequence of spinal irradiation and has limited the acceptable dose of therapeutic radiation to the cord. Over the past 10 years, the pathogenesis has been increasingly understood through the use of animal models. The importance of 'dose per fraction' and 'inter-fraction interval' have been incorporated into new mathematical models which suggest that, for small fractions, the cord may tolerate higher doses of radiation than was previously thought. Clinical recognition of the condition has improved through the description of characteristic magnetic resonance imaging changes. However little advance has been made in its treatment.
放射性脊髓炎长期以来一直被认为是脊髓照射的严重后果，并且限制了可接受的脊髓治疗性照射剂量。在过去10年中，通过使用动物模型，对其发病机制的理解日益深入。“每次分割剂量”和“分割间期”的重要性已被纳入新的数学模型，这些模型表明，对于小分割剂量，脊髓可能比以前认为的更能耐受更高剂量的辐射。通过对特征性磁共振成像变化的描述，对该病症的临床识别有所改善。然而，其治疗进展甚微。
