Barton J R, Riad M A, Gaze M N, Maran A G, Ferguson A
University of Edinburgh, Western General Hospital.
Gut. 1990 Apr;31(4):378-82. doi: 10.1136/gut.31.4.378.
Cigarette smoking influences the risk of orogastrointestinal disease in both protective (ulcerative colitis), and inductive (squamous tumours of the head, neck and oesophagus) roles. In order to study the effects of smoking on mucosal immunity, salivary immunoglobulins were measured in pure parotid saliva from groups of healthy non-smokers, smokers, and exsmokers and from patients with epithelial head and neck tumours, both untreated and after radiotherapy. Of the healthy individuals, smokers had significantly lower salivary IgA and higher IgM concentrations than did non-smokers. The effect on IgA was dose related, and reversible after cessation of smoking. Likewise, in patients with head and neck tumours (the majority being smokers), salivary IgA concentration was reduced and IgM increased when compared with non-smoking controls. Results were similar before and after radiotherapy. This study provides evidence of the effects of smoking on mucosal immunity as evaluated by parotid salivary immunoglobulins. Further studies of the influence of smoking on secretory immunity are indicated.
吸烟在口腔胃肠道疾病的发生中具有双重作用，既具有保护作用（如溃疡性结肠炎），也具有诱导作用（如头颈部和食管的鳞状肿瘤）。为了研究吸烟对黏膜免疫的影响，我们检测了健康非吸烟者、吸烟者、戒烟者以及未经治疗和放疗后的头颈部上皮肿瘤患者腮腺纯唾液中的唾液免疫球蛋白。在健康个体中，吸烟者的唾液IgA浓度显著低于非吸烟者，而IgM浓度则高于非吸烟者。对IgA的影响与吸烟剂量相关，戒烟后可恢复。同样，在头颈部肿瘤患者（大多数为吸烟者）中，与非吸烟对照组相比，唾液IgA浓度降低，IgM浓度升高。放疗前后结果相似。本研究通过腮腺唾液免疫球蛋白评估了吸烟对黏膜免疫的影响。进一步研究吸烟对分泌性免疫的影响很有必要。
