Wallers K J, McDermott P, James W B
Clin Radiol. 1981 Jul;32(4):457-9. doi: 10.1016/s0009-9260(81)80304-2.
The meglumine salts of iodoxamic and iotroxamic acids are recently developed intravenous cholangiographic media. In several studies these two media have been shown to be significantly better than meglumine iodipamide and meglumine ioglycamate for opacification of the biliary tree and incidence of adverse effects. As part of a multi-centre double-blind trial 100 patients were given iodoxamate or iotroxamate. Comparisons of opacification, side effects and renal excretion of contrast were made. The results showed no statistically significant difference in biliary tree opacification; more frequent renal excretion of contrast with iodoxamate; and contrary to previous reports a slightly higher incidence of side effects with iotroxamate.
碘氧酰胺和碘曲酰胺的葡甲胺盐是最近研制出的静脉胆管造影剂。在多项研究中，这两种造影剂在使胆管显影方面以及不良反应发生率上均显著优于碘番酸葡甲胺和碘甘葡胺。作为一项多中心双盲试验的一部分，100名患者接受了碘氧酰胺或碘曲酰胺治疗。对造影剂的显影情况、副作用及经肾排泄情况进行了比较。结果显示，在胆管显影方面无统计学显著差异；碘氧酰胺经肾排泄造影剂更为频繁；与之前的报道相反，碘曲酰胺的副作用发生率略高。
