Carbó N, Costelli P, Baccino F M, López-Soriano F J, Argilés J M
Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Biochem Biophys Res Commun. 1999 Jan 27;254(3):739-43. doi: 10.1006/bbrc.1998.9916.
Resveratrol administration to rats inoculated with a fast growing tumour (the Yoshida AH-130 ascites hepatoma) caused a very significant decrease (25%) in the tumour cell content. The effects of this diphenol were associated with an increase in the number of cells in the G2/M cell cycle phase. Interestingly, flow cytometric analysis of the tumour cell population revealed the existence of an aneuploid peak (representing 28% of total), which suggests that resveratrol causes apoptosis in the tumour cell population resulting in a decreased cell number.
给接种快速生长肿瘤（吉田AH - 130腹水型肝癌）的大鼠施用白藜芦醇，可使肿瘤细胞含量显著降低（25%）。这种双酚的作用与G2/M细胞周期阶段的细胞数量增加有关。有趣的是，对肿瘤细胞群体的流式细胞术分析显示存在一个非整倍体峰（占总数的28%），这表明白藜芦醇可导致肿瘤细胞群体发生凋亡，从而使细胞数量减少。
