与标准抗疟药物相比，本芴醇对158株塞内加尔恶性疟原虫分离株的体外活性。
In vitro activities of benflumetol against 158 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs.
作者信息
Pradines B, Tall A, Fusai T, Spiegel A, Hienne R, Rogier C, Trape J F, Le Bras J, Parzy D
机构信息
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, Marseille, France.
出版信息
Antimicrob Agents Chemother. 1999 Feb;43(2):418-20. doi: 10.1128/AAC.43.2.418.
Abstract
The 50% inhibitory concentration (IC50s) of benflumetol (range, 12.5 to 240 nM; mean, 55.1 nM) for 158 Senegalese isolates were evaluated. Ten isolates (6%) showed decreased susceptibility to benflumetol. Benflumetol was slightly more potent against chloroquine-resistant isolates (P < 0.025). No correlation or weak correlations in the responses to benflumetol and pyrimethamine, chloroquine, amodiaquine, artemether, quinine, and pyronaridine were observed, and these correlations are insufficient to suggest cross-resistance. Benflumetol may be an important alternative drug for the treatment of chloroquine-resistant malaria.
摘要
评估了本芴醇对158株塞内加尔分离株的50%抑制浓度（IC50，范围为12.5至240 nM；平均值为55.1 nM）。10株分离株（6%）对本芴醇的敏感性降低。本芴醇对氯喹耐药分离株的活性略强（P < 0.025）。未观察到本芴醇与乙胺嘧啶、氯喹、阿莫地喹、蒿甲醚、奎宁和咯萘啶反应之间的相关性或弱相关性，且这些相关性不足以提示交叉耐药。本芴醇可能是治疗氯喹耐药疟疾的一种重要替代药物。
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