Fischer T, Dahlén A, Bjarnason B
Department of Occupational Medicine, National Institute for Working Life, Solna, Sweden.
Contact Dermatitis. 1999 Jan;40(1):32-7. doi: 10.1111/j.1600-0536.1999.tb05973.x.
There remains much room for improvement in the accuracy of the patch test procedure. There has been a lack of knowledge regarding the possible relationship between the intensity of test reactions and the quality of the tape used to apply patch tests. Using different brands of tape, patches coated with 2 mg/cm2 sodium dodecyl sulfate (SLS) were applied for 24 h to the backs of 10 volunteers. The tape specimens varied in terms of manufacture, elasticity, adhesive strength, and water permeability. The intensity of patch test reactions, evaluated visually and objectively with both the high resolution laser Doppler perfusion imaging technique (HR-LDPI) and transepidermal water loss measurements (TEWL), varied significantly with the different brands of tape. Observed variations in the intensity of reactions to the patch tests could not be explained by any of the 4 tape parameters investigated. In order to attain optimal test quality in the future, both the tape and patches used in the testing system should be standardized and clearly labelled.
斑贴试验程序的准确性仍有很大的改进空间。关于试验反应强度与用于进行斑贴试验的胶带质量之间可能存在的关系，一直缺乏相关知识。使用不同品牌的胶带，将涂有2mg/cm²十二烷基硫酸钠（SLS）的贴片贴在10名志愿者的背部24小时。胶带样本在制造工艺、弹性、粘合强度和透水性方面各不相同。使用高分辨率激光多普勒灌注成像技术（HR-LDPI）和经表皮水分流失测量（TEWL）对斑贴试验反应强度进行视觉和客观评估，结果显示不同品牌的胶带会导致反应强度有显著差异。所观察到的斑贴试验反应强度变化无法用所研究的4个胶带参数中的任何一个来解释。为了在未来获得最佳的试验质量，测试系统中使用的胶带和贴片都应标准化并清晰标记。
