Birmingham A T, Galloway N R, Spencer S A
Br J Ophthalmol. 1976 Aug;60(8):568-72. doi: 10.1136/bjo.60.8.568.
Pilocarpine was administered into the conjunctival sac of normal volunteers by single-drop administration or by continuous infusion of a solution to the inner canthus by means of a fine Silastic tube. Using pupilloconstriction as a measure of response it was shown that infusion with a 0-01 per cent solution of pilocarpine was as effective as a single drop of 0-5 per cent pilocarpine. The response to the single drop was faster at onset. It was demonstrated that at pH 7-2 pilocarpine was more effective than at acid pH. The infusion method is simple to use, comfortable for long periods, has potential for reducing the need for frequent drop administration and for reducing the total amount of drug administered, and could be used for drugs other than pilocarpine.
通过单滴给药或将溶液经一根细硅橡胶管持续输注到内眦的方式，将毛果芸香碱滴入正常志愿者的结膜囊。以瞳孔收缩作为反应指标，结果表明，输注0.01%的毛果芸香碱溶液与滴入一滴0.5%的毛果芸香碱溶液效果相同。单次滴注起效更快。结果表明，在pH 7.2时毛果芸香碱比在酸性pH时更有效。输注法使用简便，长时间使用也很舒适，有可能减少频繁滴眼的需求并减少给药总量，并且可用于毛果芸香碱以外的药物。
