Wen Z Y, Song L C, Yan Z Y, Lu Z H, Sun D G, Shi Y, Chien S
Hemorheology Center, Department of Medical Physics, Beijing Medical University, PR China.
Clin Hemorheol Microcirc. 1998 Dec;19(4):299-306.
Using the model in which the entire RBC population was nearly synchronously produced following the induction of spherocytic anemia in the rabbit with antibody serum, we determined the changes of RBC osmotic fragility and deformability with aging. The results showed that the osmotic fragility increased with the RBC aging process in a nonlinear manner, being much more profound in the later part of the RBC life span. The RBC deformation index (DI) was measured by an ektacytometry. It is found that the DI decreased with RBC aging in a nonlinear fashion, with increasingly greater changes in the later part of the RBC life span. The alterations of RBC mechanical properties with aging may be attributable to a number of factors, including changes of RBC size and shape, and the viscoelasticity of the cytoplasm and membrane.
利用在兔身上用抗体血清诱导球形红细胞贫血后整个红细胞群体几乎同步产生的模型，我们测定了红细胞渗透脆性和变形性随衰老的变化。结果表明，渗透脆性随红细胞衰老过程呈非线性增加，在红细胞寿命后期更为显著。红细胞变形指数（DI）通过激光衍射法测量。发现DI随红细胞衰老呈非线性下降，在红细胞寿命后期变化越来越大。红细胞力学性质随衰老的改变可能归因于多种因素，包括红细胞大小和形状的变化，以及细胞质和细胞膜的粘弹性。
