一种苯甲酰胺衍生物3-甲氧基苯甲酰胺的致死效应可被枯草芽孢杆菌中一个细胞分裂基因ftsZ内的突变所抑制。
The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.
作者信息
Ohashi Y, Chijiiwa Y, Suzuki K, Takahashi K, Nanamiya H, Sato T, Hosoya Y, Ochi K, Kawamura F
机构信息
Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, Toshima-ku, Tokyo 171-8501, Japan.
出版信息
J Bacteriol. 1999 Feb;181(4):1348-51. doi: 10.1128/JB.181.4.1348-1351.1999.
Abstract
3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.
摘要
3-甲氧基苯甲酰胺（3-MBA）是一种已知的ADP-核糖基转移酶抑制剂，它能抑制枯草芽孢杆菌的细胞分裂，导致细胞形成丝状体并最终裂解。我们对3-MBA抗性突变体的遗传分析表明，该药物的主要靶点是在营养生长和孢子形成过程中涉及FtsZ功能的细胞分裂系统。
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