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一种苯甲酰胺衍生物3-甲氧基苯甲酰胺的致死效应可被枯草芽孢杆菌中一个细胞分裂基因ftsZ内的突变所抑制。

The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.

作者信息

Ohashi Y, Chijiiwa Y, Suzuki K, Takahashi K, Nanamiya H, Sato T, Hosoya Y, Ochi K, Kawamura F

机构信息

Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, Toshima-ku, Tokyo 171-8501, Japan.

出版信息

J Bacteriol. 1999 Feb;181(4):1348-51. doi: 10.1128/JB.181.4.1348-1351.1999.

DOI:10.1128/JB.181.4.1348-1351.1999
PMID:9973366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC93517/
Abstract

3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.

摘要

3-甲氧基苯甲酰胺（3-MBA）是一种已知的ADP-核糖基转移酶抑制剂，它能抑制枯草芽孢杆菌的细胞分裂，导致细胞形成丝状体并最终裂解。我们对3-MBA抗性突变体的遗传分析表明，该药物的主要靶点是在营养生长和孢子形成过程中涉及FtsZ功能的细胞分裂系统。

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1
The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.一种苯甲酰胺衍生物3-甲氧基苯甲酰胺的致死效应可被枯草芽孢杆菌中一个细胞分裂基因ftsZ内的突变所抑制。
J Bacteriol. 1999 Feb;181(4):1348-51. doi: 10.1128/JB.181.4.1348-1351.1999.
2
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J Bacteriol. 1996 Aug;178(16):4935-41. doi: 10.1128/jb.178.16.4935-4941.1996.
3
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本文引用的文献

1
FtsZ, a tubulin homologue in prokaryote cell division.FtsZ，原核细胞分裂中的微管同源物。
Trends Cell Biol. 1997 Sep;7(9):362-7. doi: 10.1016/S0962-8924(97)01108-2.
2
Dynamic assembly of FtsZ regulated by GTP hydrolysis.由GTP水解调节的FtsZ动态组装。
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Crystal structure of the bacterial cell-division protein FtsZ.细菌细胞分裂蛋白FtsZ的晶体结构。
Nature. 1998 Jan 8;391(6663):203-6. doi: 10.1038/34472.
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The complete genome sequence of the gram-positive bacterium Bacillus subtilis.革兰氏阳性细菌枯草芽孢杆菌的全基因组序列。
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5
Analysis of the interaction of FtsZ with itself, GTP, and FtsA.FtsZ与自身、GTP及FtsA之间相互作用的分析。
J Bacteriol. 1997 Sep;179(17):5551-9. doi: 10.1128/jb.179.17.5551-5559.1997.
6
Bacterial cell division and the Z ring.细菌细胞分裂与Z环
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7
ADP-ribosylation of proteins in Bacillus subtilis and its possible importance in sporulation.枯草芽孢杆菌中蛋白质的 ADP 核糖基化及其在孢子形成中的可能重要性。
J Bacteriol. 1996 Aug;178(16):4935-41. doi: 10.1128/jb.178.16.4935-4941.1996.
8
Changes in patterns of ADP-ribosylated proteins during differentiation of Streptomyces coelicolor A3(2) and its development mutants.天蓝色链霉菌A3(2)及其发育突变体分化过程中ADP-核糖基化蛋白质模式的变化。
J Bacteriol. 1996 Jul;178(13):3785-90. doi: 10.1128/jb.178.13.3785-3790.1996.
9
Transcription factor Spo0A switches the localization of the cell division protein FtsZ from a medial to a bipolar pattern in Bacillus subtilis.转录因子Spo0A可使枯草芽孢杆菌中细胞分裂蛋白FtsZ的定位模式从中间型转变为双极型。
Genes Dev. 1996 Feb 15;10(4):478-88. doi: 10.1101/gad.10.4.478.
10
Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers.细菌细胞分裂蛋白FtsZ组装成原丝片层和微环，它们是微管蛋白聚合物的结构同源物。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):519-23. doi: 10.1073/pnas.93.1.519.