Mori S, Crain B J, Chacko V P, van Zijl P C
Department of Radiology, Johns Hopkins Medical School, Baltimore, MD, USA.
Ann Neurol. 1999 Feb;45(2):265-9. doi: 10.1002/1531-8249(199902)45:2<265::aid-ana21>3.0.co;2-3.
The relationship between brain structure and complex behavior is governed by large-scale neurocognitive networks. The availability of a noninvasive technique that can visualize the neuronal projections connecting the functional centers should therefore provide new keys to the understanding of brain function. By using high-resolution three-dimensional diffusion magnetic resonance imaging and a newly designed tracking approach, we show that neuronal pathways in the rat brain can be probed in situ. The results are validated through comparison with known anatomical locations of such fibers.
大脑结构与复杂行为之间的关系由大规模神经认知网络所支配。因此，一种能够可视化连接功能中心的神经元投射的非侵入性技术的出现，应为理解大脑功能提供新的关键线索。通过使用高分辨率三维扩散磁共振成像和一种新设计的追踪方法，我们表明大鼠大脑中的神经元通路可以在原位进行探测。通过与这些纤维的已知解剖位置进行比较，验证了结果。
