鉴定人外周血中对自体成纤维细胞具有细胞毒性的淋巴细胞亚群。
Identification of a subpopulation of lymphocytes in human peripheral blood cytotoxic to autologous fibroblasts.
作者信息
Parkman R, Rosen F S
出版信息
J Exp Med. 1976 Dec 1;144(6):1520-30. doi: 10.1084/jem.144.6.1520.
Abstract
A naturally occurring subpopulation of human peripheral blood lymphocytes is cytotoxic to autologous and/or allogeneic fibroblasts. The autocytotoxic lymphocytes have a receptor for the third component of complement and for aggregated gamma globulin, do not form rosettes with sheep red blood cells, and are not removed by passage through nylon. The autocytotoxic subpopulation is not present in the thymus and tonsils of normal children or in the peripheral blood of individuals with X-linked agammaglobulinemia. Fibroblast absorption experiments demonstrate that the autocytotoxic cells are "sensitized" to antigens expressed on allogeneic fibroblasts in addition to the antigens expressed on autologous cells. Some normal individuals have a second subpopulation of lymphocytes that may "regulate" the autocytotoxic cells. The relevance of these observations to the murine autocytotoxic cells is discussed.
摘要
人类外周血淋巴细胞的一个天然亚群对自体和/或同种异体成纤维细胞具有细胞毒性。自体细胞毒性淋巴细胞具有补体第三成分和聚集γ球蛋白的受体，不与绵羊红细胞形成玫瑰花结，并且通过尼龙柱后不会被去除。正常儿童的胸腺和扁桃体以及X连锁无丙种球蛋白血症患者的外周血中不存在自体细胞毒性亚群。成纤维细胞吸收实验表明，自体细胞毒性细胞除了对自体细胞上表达的抗原“敏感”外，还对同种异体成纤维细胞上表达的抗原“敏感”。一些正常个体有第二个淋巴细胞亚群，可能对自体细胞毒性细胞起“调节”作用。讨论了这些观察结果与小鼠自体细胞毒性细胞的相关性。
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