Hamilton J, Vassalli J D, Reich E
J Exp Med. 1976 Dec 1;144(6):1689-94. doi: 10.1084/jem.144.6.1689.
Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.
向小鼠腹腔内注射石棉纤维会诱导形成含有产生纤溶酶原激活物的巨噬细胞的渗出物。同样，在巨噬细胞培养物中体外添加石棉会刺激纤溶酶原激活物的分泌；在这些条件下，溶菌酶和溶酶体酶的合成与分泌没有变化。暴露于石棉的巨噬细胞纤溶酶原激活物分泌增强受到低浓度抗炎类固醇的抑制。
