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Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori.多重序列分析证明了耐克拉霉素幽门螺杆菌A到G突变体的竞争生长优势。
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2
Characterisation of point mutations in domain V of the 23S rRNA gene of clinical Helicobacter pylori strains and clarithromycin-resistant phenotype in central Vietnam.中越地区临床幽门螺杆菌分离株 23S rRNA 基因 V 区点突变特征及其克拉霉素耐药表型分析。
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Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations.幽门螺杆菌23S rRNA基因两个拷贝的克隆与序列分析以及克拉霉素耐药性与23S rRNA突变的关联
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Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori.解释幽门螺杆菌临床分离株中与克拉霉素耐药相关的23S rRNA基因突变的偏差。
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Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.23S核糖体RNA的突变与幽门螺杆菌对克拉霉素的耐药性有关。
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Clarithromycin-susceptible and -resistant Helicobacter pylori isolates with identical randomly amplified polymorphic DNA-PCR genotypes cultured from single gastric biopsy specimens prior to antibiotic therapy.在抗生素治疗前，从单个胃活检标本中培养出的具有相同随机扩增多态性DNA-PCR基因型的克拉霉素敏感和耐药幽门螺杆菌分离株。
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本文引用的文献

1
Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori.解释幽门螺杆菌临床分离株中与克拉霉素耐药相关的23S rRNA基因突变的偏差。
Antimicrob Agents Chemother. 1998 Oct;42(10):2749-51. doi: 10.1128/AAC.42.10.2749.
2
Site-specific mutations in the 23S rRNA gene of Helicobacter pylori confer two types of resistance to macrolide-lincosamide-streptogramin B antibiotics.幽门螺杆菌23S rRNA基因中的位点特异性突变赋予对大环内酯-林可酰胺-链阳菌素B类抗生素的两种耐药类型。
Antimicrob Agents Chemother. 1998 Aug;42(8):1952-8. doi: 10.1128/AAC.42.8.1952.
3
Identification of a 23S rRNA gene mutation in clarithromycin-resistant Helicobacter pylori.耐克拉霉素幽门螺杆菌中23S rRNA基因突变的鉴定
Helicobacter. 1996 Dec;1(4):227-8. doi: 10.1111/j.1523-5378.1996.tb00043.x.
4
Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes.幽门螺杆菌对大环内酯类药物的耐药性：点突变的快速检测及大环内酯类药物与核糖体结合的测定
Antimicrob Agents Chemother. 1997 Dec;41(12):2724-8. doi: 10.1128/AAC.41.12.2724.
5
Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations.幽门螺杆菌23S rRNA基因两个拷贝的克隆与序列分析以及克拉霉素耐药性与23S rRNA突变的关联
Antimicrob Agents Chemother. 1997 Dec;41(12):2621-8. doi: 10.1128/AAC.41.12.2621.
6
Treatment of Helicobacter pylori infection: a review of the world literature.幽门螺杆菌感染的治疗：世界文献综述
Helicobacter. 1996 Mar;1(1):6-19. doi: 10.1111/j.1523-5378.1996.tb00003.x.
7
Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance.幽门螺杆菌23S rRNA基因中的点突变与不同水平的克拉霉素耐药性相关。
J Antimicrob Chemother. 1997 Aug;40(2):283-6. doi: 10.1093/jac/40.2.283.
8
A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori.一种用于测定克拉霉素耐药幽门螺杆菌中23S rRNA基因突变发生率的聚合酶链反应-寡核苷酸连接测定法。
Antimicrob Agents Chemother. 1997 Mar;41(3):712-4. doi: 10.1128/AAC.41.3.712.
9
Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions.紫外线诱变对非配对和错配DNA损伤处突变固定的影响。
Mol Microbiol. 1996 Nov;22(4):747-55. doi: 10.1046/j.1365-2958.1996.d01-1723.x.
10
Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.23S核糖体RNA的突变与幽门螺杆菌对克拉霉素的耐药性有关。
Antimicrob Agents Chemother. 1996 Feb;40(2):477-80. doi: 10.1128/AAC.40.2.477.

多重序列分析证明了耐克拉霉素幽门螺杆菌A到G突变体的竞争生长优势。

Multiplex sequence analysis demonstrates the competitive growth advantage of the A-to-G mutants of clarithromycin-resistant Helicobacter pylori.

作者信息

Wang G, Rahman M S, Humayun M Z, Taylor D E

机构信息

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada.

出版信息

Antimicrob Agents Chemother. 1999 Mar;43(3):683-5. doi: 10.1128/AAC.43.3.683.

DOI:10.1128/AAC.43.3.683
PMID:10049289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89182/
Abstract

Clarithromycin resistance in Helicobacter pylori is due to point mutation within the 23S rRNA. We examined the growth rates of different types of site-directed mutants and demonstrated quantitatively the competitive growth advantage of A-to-G mutants over other types of mutants by a multiplex sequencing assay. The results provide a rational explanation of why A-to-G mutants are predominantly observed among clarithromycin-resistant clinical isolates.

摘要

幽门螺杆菌对克拉霉素耐药是由于23S rRNA内的点突变所致。我们检测了不同类型定点突变体的生长速率，并通过多重测序分析定量证明了A-to-G突变体相对于其他类型突变体的竞争生长优势。这些结果为为何在克拉霉素耐药临床分离株中主要观察到A-to-G突变体提供了合理的解释。