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沙门氏菌病：从无菌猪模型中吸取的经验教训。

Salmonellosis: lessons drawn from a germ-free pig model.

作者信息

Trebichavský I, Schulze J, Dlabac V, Cukrowska B, Tlaskalová-Hogenová H, Reháková Z

机构信息

Department of Immunology and Gnotobiology, Institute of Microbiology, Prague, Czech Republic.

出版信息

Folia Microbiol (Praha). 1998;43(6):697-701. doi: 10.1007/BF02816393.

DOI:10.1007/BF02816393
PMID:10069015
Abstract

The germ-free pig model is shown to be useful for studying salmonellosis. The immune status of germ-free and infected gnotobiotic piglets is described. The regulatory role of cytokine is discussed and compared with our experimental findings.

摘要

无菌猪模型已被证明对研究沙门氏菌病有用。描述了无菌和感染的悉生仔猪的免疫状态。讨论了细胞因子的调节作用，并与我们的实验结果进行了比较。

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本文引用的文献

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Phagocytosis of Salmonellae by reticuloendothelial cells of newborn piglets lacking natural antibody.缺乏天然抗体的新生仔猪网状内皮细胞对沙门氏菌的吞噬作用。
Nature. 1963 Feb 16;197:706. doi: 10.1038/197706a0.
2
Early ontogeny of monocytes and macrophages in the pig.猪单核细胞和巨噬细胞的早期个体发育
Physiol Res. 1998;47(5):357-63.
3
Immunomodulatory effects of Bacillus firmus.坚强芽孢杆菌的免疫调节作用。
共生仔猪感染肠道病原体后，警报素 HMGB1 从小肠中释放，其在血浆中的水平反映了败血症的严重程度。
J Clin Immunol. 2011 Jun;31(3):488-97. doi: 10.1007/s10875-010-9505-3. Epub 2011 Jan 12.
4
Interference of Bifidobacterium choerinum or Escherichia coli Nissle 1917 with Salmonella Typhimurium in gnotobiotic piglets correlates with cytokine patterns in blood and intestine.双歧杆菌或大肠杆菌 Nissle 1917 对无菌仔猪中鼠伤寒沙门氏菌的干扰与血液和肠道中的细胞因子模式相关。
Clin Exp Immunol. 2011 Feb;163(2):242-9. doi: 10.1111/j.1365-2249.2010.04283.x. Epub 2010 Dec 13.
5
Innate immune response in the gut against Salmonella - review.肠道固有免疫对沙门氏菌的应答——综述。
Folia Microbiol (Praha). 2010 May;55(3):295-300. doi: 10.1007/s12223-010-0044-3. Epub 2010 Jun 6.
6
Nitric oxide metabolites in gnotobiotic piglets orally infected with Salmonella enterica serovar typhimurium.口服感染鼠伤寒沙门氏菌的悉生仔猪体内的一氧化氮代谢产物
Folia Microbiol (Praha). 2001;46(4):353-8. doi: 10.1007/BF02815626.
7
Cytokines in Salmonella infection.沙门氏菌感染中的细胞因子
Folia Microbiol (Praha). 1999;44(4):457-60. doi: 10.1007/BF02903723.
Folia Microbiol (Praha). 1997;42(4):403-8. doi: 10.1007/BF02816958.
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Cellular changes and cytokine expression in the ilea of gnotobiotic piglets resulting from peroral Salmonella typhimurium challenge.无菌仔猪经口感染鼠伤寒沙门氏菌后回肠的细胞变化及细胞因子表达
Infect Immun. 1997 Dec;65(12):5244-9. doi: 10.1128/iai.65.12.5244-5249.1997.
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Pathogenicity and protective effect of rough mutants of Salmonella species in germ-free piglets.沙门氏菌粗糙突变体在无菌仔猪中的致病性及保护作用
Infect Immun. 1997 Dec;65(12):5238-43. doi: 10.1128/iai.65.12.5238-5243.1997.
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Mast cells in infection and immunity.感染与免疫中的肥大细胞。
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TGF-beta: a critical modulator of immune cell function.转化生长因子-β：免疫细胞功能的关键调节因子。
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Maturation of the mitogen responsiveness, and IL2 and IL6 production by neonatal swine leukocytes.新生猪白细胞对丝裂原的反应性以及白细胞介素2和白细胞介素6产生的成熟过程。
Vet Immunol Immunopathol. 1997 Jun;57(1-2):105-19. doi: 10.1016/s0165-2427(96)05765-0.
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Cytokines and infectious diseases.细胞因子与传染病
Immunol Today. 1997 Feb;18(2):56-8. doi: 10.1016/s0167-5699(96)30069-8.