Singh R B, Niaz M A
Centre of Nutrition, Medical Hospital and Research Centre, Moradabad, India.
Int J Cardiol. 1999 Jan;68(1):23-9. doi: 10.1016/s0167-5273(98)00323-4.
To examine the effect of coenzyme Q10 supplementation on serum lipoprotein(a) in patients with acute coronary disease.
Randomized double blind placebo controlled trial.
Subjects with clinical diagnosis of acute myocardial infarction, unstable angina, angina pectoris (based on WHO criteria) with moderately raised lipoprotein(a) were randomized to either coenzyme Q10 as Q-Gel (60 mg twice daily) (coenzyme Q10 group, n=25) or placebo (placebo group, n=22) for a period of 28 days.
Serum lipoprotein(a) showed significant reduction in the coenzyme Q10 group compared with the placebo group (31.0% vs 8.2% P<0.001) with a net reduction of 22.6% attributed to coenzyme Q10. HDL cholesterol showed a significant increase in the intervention group without affecting total cholesterol, LDL cholesterol, and blood glucose showed a significant reduction in the coenzyme Q10 group. Coenzyme Q10 supplementation was also associated with significant reductions in thiobarbituric acid reactive substances, malon/dialdehyde and diene conjugates, indicating an overall decrease in oxidative stress.
Supplementation with hydrosoluble coenzyme Q10 (Q-Gel) decreases lipoprotein(a) concentration in patients with acute coronary disease.
研究补充辅酶Q10对急性冠状动脉疾病患者血清脂蛋白(a)的影响。
随机双盲安慰剂对照试验。
临床诊断为急性心肌梗死、不稳定型心绞痛、心绞痛（基于WHO标准）且脂蛋白(a)中度升高的患者被随机分为两组，一组服用辅酶Q10的Q-Gel制剂（每日两次，每次60毫克）（辅酶Q10组，n = 25），另一组服用安慰剂（安慰剂组，n = 22），为期28天。
与安慰剂组相比，辅酶Q10组血清脂蛋白(a)显著降低（31.0%对8.2%，P<0.001），归因于辅酶Q10的净降低率为22.6%。高密度脂蛋白胆固醇在干预组显著升高，而总胆固醇、低密度脂蛋白胆固醇未受影响，辅酶Q10组血糖显著降低。补充辅酶Q10还与硫代巴比妥酸反应性物质、丙二醛和二烯共轭物显著减少有关，表明氧化应激总体下降。
补充水溶性辅酶Q10（Q-Gel）可降低急性冠状动脉疾病患者的脂蛋白(a)浓度。
