Buffle P J, Chavaz A, Balant L
Schweiz Med Wochenschr. 1976 Nov 6;106(45):1570-1.
Serum digoxin concentration and ECG were recorded 111 times in 96 patients taking digoxin. The generally accepted ECG criteria of digoxin concentration seem greatly to overestimate the incidence of toxic cases. According to these criteria 63 ECGs in this study would have been regarded as toxic, whereas toxicity (defined by the association of serum digoxin elevation and clinical symptoms of toxicity) was actually present in only 11 cases.
对96例服用地高辛的患者进行了111次血清地高辛浓度和心电图记录。普遍认可的地高辛浓度心电图标准似乎大大高估了中毒病例的发生率。根据这些标准,本研究中的63份心电图将被视为中毒,但实际上只有11例出现了毒性反应(由血清地高辛升高与毒性临床症状相关联来定义)。