钠泵对心脏纤维细胞间通讯的影响：细胞内注射钠离子对电偶联的作用。
Influence of the sodium pump on intercellular communication in heart fibres: effect of intracellular injection of sodium ion on electrical coupling.
作者信息
De Mello W C
出版信息
J Physiol. 1976 Dec;263(2):171-97. doi: 10.1113/jphysiol.1976.sp011627.
Abstract
- The effect of intracellular sodium injection on the electrical coupling between cardiac Purkinje cells was investigated. 2. It was found that an increase in the intracellular sodium concentration produces uncoupling in about 500 sec and increases the input resistance of the injected cell. Both effects were completely reversible. 3. Inhibition of the sodium pump by ouabain (6-8 x 10(7) M) also causes electrical uncoupling. 4. The decoupling of heart cells achieved by sodium injection was considerably accelerated in fibres treated with ouabain. 5. The influence of sodium injection on cell communication seems to be related to the intracellular calcium concentration 6. The above results indicate that the maintenance of a low intracellular sodium concentration by the sodium pump is essential for the preservation of a high junctional conductance in cardiac fibres.
摘要
- 研究了向心脏浦肯野细胞内注射钠对其电耦合的影响。2. 发现细胞内钠浓度升高会在约500秒内导致解耦，并增加被注射细胞的输入电阻。这两种效应都是完全可逆的。3. 哇巴因（6 - 8×10⁻⁷ M）抑制钠泵也会导致电解耦。4. 在经哇巴因处理的纤维中，通过注射钠实现的心脏细胞解耦显著加速。5. 注射钠对细胞通讯的影响似乎与细胞内钙浓度有关。6. 上述结果表明，钠泵维持低细胞内钠浓度对于保持心脏纤维中的高连接电导至关重要。
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