小檗果实（普通小檗）对豚鼠回肠的抗组胺和抗胆碱能活性。

Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum.

作者信息

Shamsa F, Ahmadiani A, Khosrokhavar R

机构信息

Department of Chemistry, Faculty of Pharmacy, The Medical Sciences University of Tehran, Iran.

出版信息

J Ethnopharmacol. 1999 Feb;64(2):161-6. doi: 10.1016/s0378-8741(98)00122-6.

DOI:10.1016/s0378-8741(98)00122-6

PMID:10197751

Abstract

Barberry (Berberis vulgaris) is a well known medicinal plant in Iran and has also been used as food. The antihistaminic and anticholinergic activity of aqueous extract of barberry fruits were investigated on isolated guinea-pig ileum, and dose response curves of histamine and acetylcholine with and without extract were plotted. The pA2 values for antihistaminic activity of extract and dexchlorpheniramine were calculated (extract; pA2 +/- S.E.M. = 4.50 +/- 0.01[-log C (g/l)]; dexchlorpheniramine; pA2 +/- S.E.M. = 9.36 +/- 0.14[-log C (M)]) and compared with each other. The pA2 values for anticholinergic activity of extract and atropine were also calculated (extract, pA2 +/- S.E.M. = 4.37 +/- 0.03[-log C (g/l)]; atropine, pA2 +/- S.E.M. = 8.99 +/- 0.13[-log C (M)]) and compared. The results indicated antihistaminic and anticholinergic activity of extract that seems to be of the competitive type.

摘要

伏牛花（小檗）是伊朗一种著名的药用植物，也被用作食物。研究了伏牛花果实水提取物对离体豚鼠回肠的抗组胺和抗胆碱活性，并绘制了有提取物和无提取物时组胺和乙酰胆碱的剂量反应曲线。计算了提取物和右氯苯那敏抗组胺活性的pA2值（提取物；pA2±标准误=4.50±0.01[-log C（g/l）]；右氯苯那敏；pA2±标准误=9.36±0.14[-log C（M）]）并相互比较。还计算了提取物和阿托品抗胆碱活性的pA2值（提取物，pA2±标准误=4.37±0.03[-log C（g/l）]；阿托品，pA2±标准误=8.99±0.13[-log C（M）]）并进行比较。结果表明提取物具有抗组胺和抗胆碱活性，似乎属于竞争性类型。