大肠埃希菌和肺炎克雷伯菌临床分离株中超广谱β-内酰胺酶的调查：韩国TEM-52的流行情况
Survey of extended-spectrum beta-lactamases in clinical isolates of Escherichia coli and Klebsiella pneumoniae: prevalence of TEM-52 in Korea.
作者信息
Pai H, Lyu S, Lee J H, Kim J, Kwon Y, Kim J W, Choe K W
机构信息
Division of Infectious Disease, Department of Internal Medicine, College of Medicine, University of Dankook, Chonan, Seoul, Korea.
出版信息
J Clin Microbiol. 1999 Jun;37(6):1758-63. doi: 10.1128/JCM.37.6.1758-1763.1999.
Abstract
Two hundred ninety isolates of Escherichia coli were investigated for the production of extended-spectrum beta-lactamases (ESBLs). Fourteen (4.8%) of the 290 strains were found to produce ESBLs. Each of the 14 strains produced one or two ESBLs, as follows: 10 strains produced TEM-52, 1 strain produced SHV-2a, 1 strain produced SHV-12, 1 strain produced a CMY-1-like enzyme, and 1 strain expressed SHV-2a and a CMY-1-like enzyme. Another two strains for which the MICs of ceftazidime and cefoxitin were high, were probable AmpC enzyme hyperproducers. Because of the high prevalence of TEM-52 in E. coli isolates, we further investigated the TEM-type ESBLs produced by Klebsiella pneumoniae in order to observe the distribution of TEM-52 enzymes among Enterobacteriaceae in Korea. All TEM enzymes produced by 12 strains of K. pneumoniae were identified as TEM-52. To evaluate the genetic relatedness among the organisms, ribotyping of TEM-52-producing E. coli and K. pneumoniae was performed. The ribotyping profiles of the organisms showed similar but clearly different patterns. In conclusion, TEM-52 is the most prevalent TEM-type ESBL in Korea.
摘要
对290株大肠杆菌进行了超广谱β-内酰胺酶（ESBLs）产生情况的调查。在这290株菌株中，有14株（4.8%）被发现可产生ESBLs。14株中的每一株都产生一种或两种ESBLs，具体如下：10株产生TEM-52，1株产生SHV-2a，1株产生SHV-12，1株产生一种CMY-1样酶，还有1株同时表达SHV-2a和一种CMY-1样酶。另外两株头孢他啶和头孢西丁的最低抑菌浓度（MIC）较高，可能是AmpC酶高产菌株。由于TEM-52在大肠杆菌分离株中普遍存在，我们进一步研究了肺炎克雷伯菌产生的TEM型ESBLs，以观察TEM-52酶在韩国肠杆菌科细菌中的分布情况。12株肺炎克雷伯菌产生的所有TEM酶均被鉴定为TEM-52。为评估这些菌株之间的遗传相关性，对产生TEM-52的大肠杆菌和肺炎克雷伯菌进行了核糖体分型。这些菌株的核糖体分型图谱显示出相似但明显不同的模式。总之，TEM-52是韩国最常见的TEM型ESBL。
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