Tibby S M, Hatherill M, Murdoch I A
Department of Paediatric Intensive Care, Guy's Hospital, London, UK.
Arch Dis Child. 1999 Feb;80(2):163-6. doi: 10.1136/adc.80.2.163.
Capillary refill time is an important diagnostic adjunct in the acute resuscitation phase of the shocked child. This study assesses its relation to commonly measured haemodynamic parameters in the postresuscitation phase when the child has reached the intensive care unit, and compares this with core-peripheral temperature gap.
Ninety standardised measurements of capillary refill time were made on 55 patients, who were divided into postcardiac surgery (n = 27), and general (n = 28), most of whom had septic shock (n = 24). A normal capillary refill time was defined as < or = 2 seconds. Measured haemodynamic variables included: cardiac index, central venous pressure, systemic vascular resistance index, stroke volume index (SVI), and blood lactate. Seventy measurements were made on patients while being treated with inotropes or vasodilators.
Capillary refill time and temperature gap both correlated poorly with all haemodynamic variables among post-cardiac surgery children. For general patients, capillary refill time was related to SVI and lactate; temperature gap correlated poorly with all variables. General patients with a prolonged capillary refill time had a lower median SVI (28 v 38 ml/m2) but not a higher lactate (1.7 v 1.1 mmol/l). A capillary refill time of > or = 6 seconds had the best predictive value for a reduced SVI.
Among ventilated, general intensive care patients, capillary refill time is related weakly to blood lactate and SVI. A normal value for capillary refill time of < or = 2 seconds has little predictive value and might be too conservative for this population; septic shock.
毛细血管再充盈时间是休克患儿急性复苏阶段的一项重要诊断辅助指标。本研究评估其在患儿进入重症监护病房后的复苏后阶段与常用血流动力学参数的关系,并将其与核心 - 外周体温差进行比较。
对55例患者进行了90次标准化的毛细血管再充盈时间测量,这些患者分为心脏手术后组(n = 27)和普通组(n = 28),其中大多数患有脓毒性休克(n = 24)。正常的毛细血管再充盈时间定义为≤2秒。测量的血流动力学变量包括:心脏指数、中心静脉压、全身血管阻力指数、每搏量指数(SVI)和血乳酸。在患者接受正性肌力药物或血管扩张剂治疗时进行了70次测量。
在心脏手术后的儿童中,毛细血管再充盈时间和体温差与所有血流动力学变量的相关性均较差。对于普通患者,毛细血管再充盈时间与SVI和乳酸有关;体温差与所有变量的相关性较差。毛细血管再充盈时间延长的普通患者的SVI中位数较低(28 vs 38 ml/m²),但乳酸水平并不更高(1.7 vs 1.1 mmol/L)。毛细血管再充盈时间≥6秒对降低的SVI具有最佳预测价值。
在接受通气的普通重症监护患者中,毛细血管再充盈时间与血乳酸和SVI的相关性较弱。≤2秒的正常毛细血管再充盈时间预测价值不大,对于该人群(脓毒性休克)可能过于保守。