Reinhard K H
Apotheke am Oswaldgarten, Giessen, Germany.
J Altern Complement Med. 1999 Apr;5(2):143-51. doi: 10.1089/acm.1999.5.143.
Recently, Uncaria tomentosa (Willd.) D.C. has become known as a healing plant with an ethnomedicinal background. There have been several reports on its constituents, in particular, oxindole alkaloids. It was found that 2 chemotypes of Uncaria tomentosa with different alkaloid patterns occur in nature. The roots of one type contain pentacyclic oxindoles and the other contains tetracyclic oxindoles. This difference should be considered when the plant is to be used for medicinal applications. Tetracyclic oxindole alkaloids act on the central nervous system, whereas pentacyclic oxindole alkaloids affect the cellular immune system. Recent studies have shown that the tetracyclic alkaloids exert antagonistic effects on the action of the pentacyclic alkaloids. Mixtures of these 2 types of drugs are therefore unsuitable for medicinal uses.
最近，猫爪草（Uncaria tomentosa (Willd.) D.C.）作为一种具有民族药用背景的治疗植物而闻名。关于其成分，特别是氧化吲哚生物碱，已有多篇报道。研究发现，自然界中存在两种具有不同生物碱模式的猫爪草化学型。一种类型的根含有五环氧化吲哚，另一种含有四环氧化吲哚。在将该植物用于药用时应考虑这种差异。四环氧化吲哚生物碱作用于中枢神经系统，而五环氧化吲哚生物碱影响细胞免疫系统。最近的研究表明，四环生物碱对五环生物碱的作用具有拮抗作用。因此，这两种药物的混合物不适合药用。
