Ampollini P, Marchesi C, Signifredi R, Ghinaglia E, Scardovi F, Codeluppi S, Maggini C
Istituto di Clinical Psichiatrica, Università di Parma, Italy.
J Affect Disord. 1999 Jan-Mar;52(1-3):203-7. doi: 10.1016/s0165-0327(98)00048-2.
Forty-two patients with Panic Disorder (P), 18 with Major Depression (MD), 35 with both conditions (MIX) and 45 healthy subjects (C) were tested with the Tridimensional Personality Questionnaire and the Structured Interview for DSM-III-R Personality Disorders.
A different prevalence of Dependent (P = 16.7%, MD = 5.6%, MIX = 41.4%, C = 2.1%) (P < 0.001), Obsessive-Compulsive (P = 4.8%, MD = 27.8%, MIX = 3.4%, C = 0%) (P < 0.001) and Histrionic (P =23.8%, MD = 0%, MIX = 31%, C = 4.2%) (P = 0.001) personality disorders (PD) was found among groups. Harm Avoidance (HA) (P < 0.001) and Reward Dependence (RD) (P <0.001) were higher in patients than in controls. As expected the patients with comorbid conditions (MIX) showed higher HA levels (P < 0.01) and a greater prevalence of PDs, particularly of Cluster C compared to patients with pure disorders.
This study suggests that high HA and RD scores are associated with P, MD and MIX, and the former dimension is even higher in MIX patients.
采用三维人格问卷和DSM-III-R人格障碍结构化访谈对42例惊恐障碍患者（P组）、18例重度抑郁症患者（MD组）、35例同时患有这两种疾病的患者（混合组，MIX组）和45名健康受试者（C组）进行测试。
发现各组之间依赖型人格障碍（P组 = 16.7%，MD组 = 5.6%，混合组 = 41.4%，C组 = 2.1%）（P < 0.001）、强迫型人格障碍（P组 = 4.8%，MD组 = 27.8%，混合组 = 3.4%，C组 = 0%）（P < 0.001）和表演型人格障碍（P组 = 23.8%，MD组 = 0%，混合组 = 31%，C组 = 4.2%）（P = 0.001）的患病率存在差异。患者的回避伤害（HA）（P < 0.001）和奖赏依赖（RD）（P < 0.001）水平高于对照组。正如预期的那样，与单纯疾病患者相比，合并症患者（混合组）表现出更高的HA水平（P < 0.01）和更高的人格障碍患病率，尤其是C类人格障碍。
本研究表明，高HA和RD得分与惊恐障碍、重度抑郁症和混合组相关，并且在前述维度上，混合组患者的得分更高。
