Fatemi M, Greenleaf J F
Ultrasound Research, Department of Physiology and Biophysics, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6603-8. doi: 10.1073/pnas.96.12.6603.
We describe theoretical principles of an imaging modality that uses the acoustic response of an object to a highly localized dynamic radiation force of an ultrasound field. In this method, named ultrasound-stimulated vibro-acoustography (USVA), ultrasound is used to exert a low-frequency (in kHz range) force on the object. In response, a portion of the object vibrates sinusoidally in a pattern determined by its viscoelastic properties. The acoustic emission field resulting from object vibration is detected and used to form an image that represents both the ultrasonic and low-frequency (kHz range) mechanical characteristics of the object. We report the relation between the emitted acoustic field and the incident ultrasonic pressure field in terms of object parameters. Also, we present the point-spread function of the imaging system. The experimental images in this report have a resolution of about 700 microm, high contrast, and high signal-to-noise ratio. USVA is sensitive enough to detect object motions on the order of nanometers. Possible applications include medical imaging and material evaluation.
我们描述了一种成像模态的理论原理,该模态利用物体对超声场高度局部化动态辐射力的声学响应。在这种名为超声激发振动声成像(USVA)的方法中,超声用于对物体施加低频(千赫兹范围)力。作为响应,物体的一部分会以由其粘弹性特性决定的模式进行正弦振动。检测由物体振动产生的声发射场,并用于形成一幅表示物体超声和低频(千赫兹范围)机械特性的图像。我们根据物体参数报告发射声场与入射超声压力场之间的关系。此外,我们还给出了成像系统的点扩散函数。本报告中的实验图像分辨率约为700微米,具有高对比度和高信噪比。USVA灵敏度足以检测纳米级别的物体运动。可能的应用包括医学成像和材料评估。