Tetley T D, Hext P M, Richards R J, McDermott M
Br J Exp Pathol. 1976 Oct;57(5):505-14.
Rats inhaling chrysotile asbestos contracted asbestosis and fibrosis of the lungs. Studies of biochemical and morphological changes (between normal and treated animals) show that chrysotile induces an increase in the lung free cell population and pulmonary surfactant levels. Lysosomal enzyme levels are elevated in both the whole lung and free cell population and there are considerable changes in macrophage morphology. It is suggested that the primary response of the lung to chrysotile is an increase in surfactant production coupled with an increase in free cell numbers, in order to prevent the cytotoxic effect of the dust.
吸入温石棉的大鼠患上了石棉肺和肺部纤维化。对（正常动物与接受治疗动物之间的）生化和形态学变化的研究表明，温石棉会导致肺游离细胞数量和肺表面活性物质水平增加。全肺和游离细胞群体中的溶酶体酶水平均升高，巨噬细胞形态也有显著变化。有人认为，肺对温石棉的主要反应是表面活性物质产生增加以及游离细胞数量增加，以防止粉尘的细胞毒性作用。
