温石棉粉尘暴露大鼠肺表面活性物质及磷脂酰胆碱代谢的变化
Changes in pulmonary surfactant and phosphatidylcholine metabolism in rats exposed to chrysotile asbestos dust.
作者信息
Tetley T D, Richards R J, Harwood J L
出版信息
Biochem J. 1977 Sep 15;166(3):323-9. doi: 10.1042/bj1660323.
Abstract
- Pulmonary surfactant was isolated from rats that had been exposed to chrysotile asbestos dust for from 3 days to 15 weeks. 2. Asbestos-treated rats showed a progressive increase in amounts of surfactant. After 15 weeks, treated animals contained 4 times as much as non-treated. 3. No significant change was seen in the total protein or total fatty acid composition of surfactant with exposure. 4. The increase in surfactant phosphatidylcholine normally seen on maturation of rat lung was accelerated by exposure of animals to asbestos. 5. An increase in the activity of phosphorylcholine glyceride transferase in lung homogenates and free cell populations was found. 6. Lysosomal phospholipase A was relatively unaffected by dust exposure. 7. It is suggested that the increase in surfactant amounts could be due to an increase in its synthesis without a corresponding alteration in its degradation.
摘要
- 从暴露于温石棉粉尘3天至15周的大鼠中分离出肺表面活性剂。2. 经石棉处理的大鼠肺表面活性剂含量呈逐渐增加趋势。15周后，处理组动物的肺表面活性剂含量是未处理组的4倍。3. 随着暴露时间的增加，表面活性剂的总蛋白或总脂肪酸组成未见明显变化。4. 动物接触石棉会加速大鼠肺成熟过程中正常出现的表面活性剂磷脂酰胆碱的增加。5. 发现肺匀浆和游离细胞群体中磷酸胆碱甘油酯转移酶的活性增加。6. 溶酶体磷脂酶A相对不受粉尘暴露的影响。7. 提示表面活性剂含量的增加可能是由于其合成增加而降解未发生相应改变所致。
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