Velten I M, Korth M, Horn F K, Budde W M
Department of Ophthalmology, University of Erlangen-Nürnberg, Germany.
Br J Ophthalmol. 1999 Feb;83(2):199-205. doi: 10.1136/bjo.83.2.199.
To evaluate temporal contrast sensitivity with full field, peripheral, and central stimulation and to determine the most sensitive corresponding retinal area for glaucoma damage.
Temporal contrast sensitivity was determined either with a full field, a peripheral annular area from 30 degrees to 90 degrees, or a central area from 0 degree to 30 degrees at a frequency of 37.1 Hz. 232 eyes of 232 subjects were included. They were classified into four groups: eyes with ocular hypertension (OHT, n = 54), "preperimetric" glaucomas (n = 73) with glaucomatous optic disc abnormalities but no visual field loss, "perimetric" glaucomas (n = 53) with visual field loss, and 52 normals.
In all four groups, temporal contrast sensitivity was almost equal with full field and peripheral, but significantly higher than with central stimulation (p < 0.001). With regard to the diagnostic power of the three different stimulus areas, OHTs and glaucomas were found to be best discriminated from normals by peripheral stimulation.
According to these results, temporal contrast sensitivity seems to be determined by peripheral retinal areas. As the diagnostic power of the three different stimulus areas was best with the peripheral stimulation, this condition should be used for early glaucoma diagnosis.
评估全视野、周边及中央刺激下的时间对比敏感度，并确定青光眼损害最敏感的相应视网膜区域。
在37.1Hz频率下，通过全视野、30度至90度的周边环形区域或0度至30度的中央区域来测定时间对比敏感度。纳入232名受试者的232只眼睛。他们被分为四组：高眼压症患者（OHT，n = 54）、“视野缺损前期”青光眼患者（n = 73），有青光眼性视盘异常但无视野缺损、“视野缺损期”青光眼患者（n = 53）有视野缺损，以及52名正常人。
在所有四组中，全视野和周边刺激下的时间对比敏感度几乎相等，但显著高于中央刺激下的敏感度（p < 0.001）。关于三种不同刺激区域的诊断能力，发现通过周边刺激能最好地区分高眼压症患者和青光眼患者与正常人。
根据这些结果，时间对比敏感度似乎由周边视网膜区域决定。由于三种不同刺激区域中周边刺激的诊断能力最佳，这种情况应用于早期青光眼诊断。
