多种化学物质在体外对大肠杆菌marRAB基因座的负调控因子MarR阻遏活性的改变。
Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro.
作者信息
Alekshun M N, Levy S B
机构信息
Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
出版信息
J Bacteriol. 1999 Aug;181(15):4669-72. doi: 10.1128/JB.181.15.4669-4672.1999.
Abstract
MarR negatively regulates expression of the multiple antibiotic resistance operon (marRAB) in Escherichia coli. In this study, it was demonstrated that sodium salicylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affect its repressor activity.
摘要
MarR对大肠杆菌中多重抗生素耐药操纵子（marRAB）的表达起负调控作用。在本研究中，已证明水杨酸钠、白花丹素、2,4-二硝基苯酚和甲萘醌（全细胞中marRAB操纵子的诱导剂）均在体外干扰MarR的阻遏活性。有人提出，这些化合物可直接与MarR相互作用以影响其阻遏活性。
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Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro.多种化学物质在体外对大肠杆菌marRAB基因座的负调控因子MarR阻遏活性的改变。
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