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多种化学物质在体外对大肠杆菌marRAB基因座的负调控因子MarR阻遏活性的改变。

Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro.

作者信息

Alekshun M N, Levy S B

机构信息

Center for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

出版信息

J Bacteriol. 1999 Aug;181(15):4669-72. doi: 10.1128/JB.181.15.4669-4672.1999.

DOI:10.1128/JB.181.15.4669-4672.1999
PMID:10419969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC103602/
Abstract

MarR negatively regulates expression of the multiple antibiotic resistance operon (marRAB) in Escherichia coli. In this study, it was demonstrated that sodium salicylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affect its repressor activity.

摘要

MarR对大肠杆菌中多重抗生素耐药操纵子（marRAB）的表达起负调控作用。在本研究中，已证明水杨酸钠、白花丹素、2,4-二硝基苯酚和甲萘醌（全细胞中marRAB操纵子的诱导剂）均在体外干扰MarR的阻遏活性。有人提出，这些化合物可直接与MarR相互作用以影响其阻遏活性。

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本文引用的文献

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Characterization of MarR superrepressor mutants.MarR超级阻遏物突变体的表征
J Bacteriol. 1999 May;181(10):3303-6. doi: 10.1128/JB.181.10.3303-3306.1999.
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Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter.多药转运蛋白转录激活因子BmrR对多种药物识别的结构基础
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Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains.鼠伤寒沙门氏菌的多药外排泵AcrAB仅排泄那些含有亲脂性侧链的β-内酰胺类抗生素。
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