应激与细胞核：基因表达动力学和结构重组
Stress and the cell nucleus: dynamics of gene expression and structural reorganization.
作者信息
Jolly C, Morimoto R I
机构信息
Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA.
出版信息
Gene Expr. 1999;7(4-6):261-70.
Abstract
A growing number of experimental observations reveal that the cell nucleus is functionally compartmentalized yet organized to ensure a dynamic response to events that influence nuclear activities. The cellular and molecular response to physiological and environmental stress induces a rapid and transient change in gene expression associated with major changes in nuclear architecture that impacts on signals involved in cell growth. In this review, we will address the effects of stress on the functional compartmentation of the cell nucleus and the dynamic reorganization of nuclear structures and function.
摘要
越来越多的实验观察表明，细胞核在功能上是分区的，但又是有组织的，以确保对影响核活动的事件做出动态反应。细胞对生理和环境应激的细胞与分子反应会诱导基因表达的快速和短暂变化，这与核结构的重大变化相关，而核结构的变化会影响细胞生长相关的信号。在这篇综述中，我们将探讨应激对细胞核功能分区以及核结构与功能动态重组的影响。
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