胃肠道中的基因转移。
Gene transfer in the gastrointestinal tract.
作者信息
Netherwood T, Bowden R, Harrison P, O'Donnell A G, Parker D S, Gilbert H J
机构信息
Department of Biological and Nutritional Sciences, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne NE1 7RU, Great Britain.
出版信息
Appl Environ Microbiol. 1999 Nov;65(11):5139-41. doi: 10.1128/AEM.65.11.5139-5141.1999.
Abstract
The maximum in vivo transfer rate of plasmid pAMbeta1 in the gut was 0.03 transconjugant per recipient cell, and this rate could be simulated in vitro only by forced filter mating. Transfer was not detected in liquid culture matings. Our findings demonstrate that in vitro methods, such as forced filter mating and liquid mating, underestimate the in vivo rates of gene transfer.
摘要
质粒pAMbeta1在肠道内的最大体内转移率为每受体细胞0.03个转接合子，且该速率仅能通过强制滤膜交配在体外模拟。在液体培养交配中未检测到转移。我们的研究结果表明，体外方法，如强制滤膜交配和液体交配，低估了体内基因转移速率。
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