Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts 02155, USA; email:
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA; email:
Annu Rev Biomed Eng. 2018 Jun 4;20:277-300. doi: 10.1146/annurev-bioeng-062117-121019. Epub 2018 Mar 12.
An increasing number of studies have strongly correlated the composition of the human microbiota with many human health conditions and, in several cases, have shown that manipulating the microbiota directly affects health. These insights have generated significant interest in engineering indigenous microbiota community members and nonresident probiotic bacteria as biotic diagnostics and therapeutics that can probe and improve human health. In this review, we discuss recent advances in synthetic biology to engineer commensal and probiotic lactic acid bacteria, bifidobacteria, and Bacteroides for these purposes, and we provide our perspective on the future potential of these technologies.
越来越多的研究强烈表明人类微生物组的组成与许多人类健康状况密切相关，并且在某些情况下表明直接操纵微生物组会影响健康。这些见解引起了人们对工程化本土微生物群成员和非驻留益生菌的浓厚兴趣，将其作为生物诊断和治疗方法，可用于探索和改善人类健康。在这篇综述中，我们讨论了合成生物学在为这些目的工程化共生和益生菌乳杆菌、双歧杆菌和拟杆菌方面的最新进展，并提供了我们对这些技术未来潜力的看法。
