Tu B L, Kelly K A
Department of Surgery, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA.
J Gastrointest Surg. 1999 Nov-Dec;3(6):613-7. doi: 10.1016/s1091-255x(99)80083-3.
We wondered whether the slow gastric emptying of the Roux stasis syndrome could be improved by performing a corrective "uncut" Roux operation. Five dogs had a standard Roux gastrectomy and placement of serosal electrodes on the proximal jejunum and Roux limb. After recovery, baseline myoelectrical and gastric emptying data were collected. The animals then underwent a second operation: take down of the Roux limb, restoration of jejunal continuity, and construction of an "uncut" Roux limb. After the animals recovered, the tests were repeated. The slow frequency of pacesetter potentials (PPs) in the standard Roux limb (mean +/- standard error of the mean 14 +/- 0.4 cpm) was unchanged after the uncut Roux operation (14 +/- 0.5 cpm, P > 0.05). However, a greater percentage of PPs propagated aborally in the uncut Roux limb (81% +/- 4%) than in the standard Roux limb (53% +/- 7%, P <0.05). Nonetheless, gastric emptying of a 250 ml 10% dextrose liquid meal was not speeded by the uncut Roux operation (uncut Roux = 36% +/- 5% emptied by 20 minutes vs. standard Roux = 35% +/- 7%; P >0.05). Bile acid concentrations in gastric aspirates were minimal after both operations (0.7 +/- 0.2 micromol/L vs. 0.6 +/- 0.1 micromol/L; P >0.05). The conclusion was that more PPs propagated in the aborad direction in the uncut Roux limb than in the standard Roux limb, but gastric emptying was not speeded by the uncut Roux operation. Both operations were equally effective in preventing bile reflux into the gastric remnant.
我们想知道,通过实施纠正性“未切断”Roux手术,Roux淤滞综合征的胃排空缓慢情况是否能够得到改善。五只狗接受了标准的Roux胃切除术,并在空肠近端和Roux袢放置了浆膜电极。恢复后,收集基础肌电和胃排空数据。然后这些动物接受第二次手术:拆除Roux袢,恢复空肠连续性,并构建“未切断”Roux袢。动物恢复后,重复进行测试。标准Roux袢中起搏电位(PPs)的缓慢频率(平均值±平均标准误差为14±0.4次/分钟)在未切断Roux手术后未发生变化(14±0.5次/分钟,P>0.05)。然而,与标准Roux袢(53%±7%)相比,未切断Roux袢中有更大比例的PPs向口外传播(81%±4%,P<0.05)。尽管如此,未切断Roux手术并未加快250毫升10%葡萄糖流食的胃排空速度(未切断Roux手术20分钟排空36%±5%,标准Roux手术排空35%±7%;P>0.05)。两次手术后胃吸出物中的胆汁酸浓度均极低(0.7±0.2微摩尔/升对0.6±0.1微摩尔/升;P>0.05)。结论是,与标准Roux袢相比,未切断Roux袢中有更多的PPs向口外方向传播,但未切断Roux手术并未加快胃排空速度。两种手术在预防胆汁反流至胃残端方面同样有效。