意大利中部肺炎链球菌菌株中mefE、erm和tet(M)基因的流行情况。
Prevalence of mefE, erm and tet(M) genes in Streptococcus pneumoniae strains from Central Italy.
作者信息
Latini L, Ronchetti M P, Merolla R, Merolla R, Guglielmi F, Bajaksouzian S, Villa M P, Jacobs M R, Ronchetti R
机构信息
Department of Pediatrics, University of Rome La Sapienza, Italy.
出版信息
Int J Antimicrob Agents. 1999 Sep;13(1):29-33. doi: 10.1016/s0924-8579(99)00097-7.
One hundred and seventy-three Streptococcus pneumoniae strains isolated from surveillance studies conducted in daycare centres were studied. The mefE, erm and tet(M) genes were detected in 16.2, 45.1 and 47.4% of isolates respectively. Agreement between PCR results and antibiotic susceptibility patterns was 100%. Macrolide resistance was due to the presence of erm in 73.6% of strains and to the presence of mefE in the remaining 26.4%. All tetracycline resistant strains carried the tet(M) gene. erm was associated with tet(M) in 98.7% of strains, whereas no isolate carrying mefE carried tet(M). A significant association was found between mefE and serogroup 6 (P < 0.0005) and between erm and tet(M) and serogroup 19 (P < 0.00001).
对从日托中心进行的监测研究中分离出的173株肺炎链球菌菌株进行了研究。分别在16.2%、45.1%和47.4%的分离株中检测到mefE、erm和tet(M)基因。PCR结果与抗生素敏感性模式之间的一致性为100%。73.6%的菌株对大环内酯类抗生素耐药是由于erm的存在，其余26.4%是由于mefE的存在。所有四环素耐药菌株均携带tet(M)基因。98.7%的菌株中erm与tet(M)相关，而携带mefE的分离株均未携带tet(M)。发现mefE与血清群6之间存在显著关联（P < 0.0005），erm与tet(M)以及血清群19之间存在显著关联（P < 0.00001）。
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