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作为从大肠杆菌中分离出的1类整合子中的一个基因盒的新型链霉素和壮观霉素抗性基因。

Novel streptomycin and spectinomycin resistance gene as a gene cassette within a class 1 integron isolated from Escherichia coli.

作者信息

Sandvang D

机构信息

Danish Veterinary Laboratory, DK-1790 Copenhagen V, and Department of Microbiology, The Royal Veterinary and Agricultural University, DK-1870 Frederiksberg C, Denmark.

出版信息

Antimicrob Agents Chemother. 1999 Dec;43(12):3036-8. doi: 10.1128/AAC.43.12.3036.

DOI:10.1128/AAC.43.12.3036
PMID:10582907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89612/
Abstract

The aadA genes, encoding resistance to streptomycin and spectinomycin, have been found as gene cassettes in different gram-negative and gram-positive bacterial species. The present study has revealed the sequence of a new gene, aadA5, integrated as a gene cassette together with the trimethoprim resistance gene dfr7 in a class 1 integron. The integron was located on a plasmid and was identified in a pathogenic porcine Escherichia coli isolate.

摘要

编码对链霉素和壮观霉素耐药性的aadA基因已在不同的革兰氏阴性和革兰氏阳性细菌物种中作为基因盒被发现。本研究揭示了一个新基因aadA5的序列，它与甲氧苄啶耐药基因dfr7一起作为一个基因盒整合在1类整合子中。该整合子位于一个质粒上，在一株致病性猪源大肠杆菌分离株中被鉴定出来。

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本文引用的文献

1
Detection of a streptomycin/spectinomycin adenylyltransferase gene (aadA) in Enterococcus faecalis.粪肠球菌中链霉素/壮观霉素腺苷酸转移酶基因（aadA）的检测
Antimicrob Agents Chemother. 1999 Jan;43(1):157-60. doi: 10.1128/AAC.43.1.157.
2
Structure and function of 59-base element recombination sites associated with mobile gene cassettes.与移动基因盒相关的59碱基元件重组位点的结构与功能
Mol Microbiol. 1997 Nov;26(4):731-45. doi: 10.1046/j.1365-2958.1997.6091980.x.
3
Characterisation of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimurium DT104.丹麦多重耐药肠炎沙门氏菌鼠伤寒血清型DT104中整合子及抗生素抗性基因的特征分析
FEMS Microbiol Lett. 1997 Dec 1;157(1):177-81. doi: 10.1111/j.1574-6968.1997.tb12770.x.
4
Plasmid pDGO100 contains a second integron with the trimethoprim resistance gene dfrA7 as the inserted cassette.质粒pDGO100含有第二个整合子，其中插入的盒式结构为甲氧苄啶抗性基因dfrA7。
Plasmid. 1996 Jan;35(1):67-70. doi: 10.1006/plas.1996.0008.
5
Gene cassettes: a new class of mobile element.基因盒：一类新型可移动元件。
Microbiology (Reading). 1995 Dec;141 ( Pt 12):3015-27. doi: 10.1099/13500872-141-12-3015.
6
The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants.整合子的3'保守区段含有一个与对防腐剂和消毒剂的多药耐药性相关的基因。
Antimicrob Agents Chemother. 1993 Apr;37(4):761-8. doi: 10.1128/AAC.37.4.761.
7
Characterization of transposon Tn5086, carrying the site-specifically inserted gene dhfrVII mediating trimethoprim resistance.携带位点特异性插入基因dhfrVII介导甲氧苄啶抗性的转座子Tn5086的特性分析。
J Bacteriol. 1993 Mar;175(6):1796-805. doi: 10.1128/jb.175.6.1796-1805.1993.
8
Revised analysis of aadA2 gene of plasmid pSa.质粒pSa的aadA2基因的修订分析
Antimicrob Agents Chemother. 1994 May;38(5):1172-5. doi: 10.1128/AAC.38.5.1172.
9
Expression of antibiotic resistance genes in the integrated cassettes of integrons.整合子整合盒中抗生素抗性基因的表达。
Antimicrob Agents Chemother. 1995 Jan;39(1):155-62. doi: 10.1128/AAC.39.1.155.
10
Rapid procedure for detection and isolation of large and small plasmids.用于检测和分离大小质粒的快速方法。
J Bacteriol. 1981 Mar;145(3):1365-73. doi: 10.1128/jb.145.3.1365-1373.1981.