Marcus J T, DeWaal L K, Götte M J, van der Geest R J, Heethaar R M, Van Rossum A C
Dept of Clinical Physics and Informatics, Vrije Universiteit Amsterdam, The Netherlands.
Int J Card Imaging. 1999 Oct;15(5):411-9. doi: 10.1023/a:1006268405585.
To obtain normal values of left ventricular (LV) end-diastolic volume (EDV), stroke volume (SV), cardiac output (CO) and LV mass, in relation to gender, weight (W), length (L) and body surface area (BSA).
Sixty-one healthy volunteers (32 male, 22.4 +/- 2.2 years) were examined, weight was 70.9 +/- 12.2 kg, length was 1.78 +/- 0.09 m, BSA was 1.88 +/- 0.19 m2. Segmented k-space breathhold cine MRI was used to obtain a stack of parallel short-axis images, from which LV volumes and end-diastolic mass were derived by slice summation. Four different body size indices were studied: W, L, L2 and BSA.
After indexing for L, L2 and BSA, the gender differences in all LV parameters are still persisting. After indexing for W, gender differences persist for EDV and EDM, but are no longer observed for SV and CO. Separate regression analyses for males and females were performed. EDV, SV, CO and EDM correlated significantly with each body size index, both in males and in females. L or BSA were in general better predictors for LV parameters than W. Linear regression equations of EDV (ml) vs. L(m) were for males: EDV = 275 x L - 359 and for females: EDV = 190 x L - 215. Equations of SV(ml) vs. L were for males: SV = 186 x L - 237 and for females: SV = 118 x L - 121. Equations of LV mass(g) vs. L were for males: Mass = 175 x L - 179 and for females: Mass = 65.8 x L - 10.9.
Most gender differences in LV parameters remain even after correction for body size indices. Normal reference values for LV parameters are given in relation to body size indices, by calculating regression coefficients separately for males and females. These normal values serve to obtain more accurate reference values for a patient with given gender, weight and length, and thus to improve the differentiation between normal and abnormal LV parameters.
获取左心室（LV）舒张末期容积（EDV）、每搏输出量（SV）、心输出量（CO）和左心室质量的正常值，并研究其与性别、体重（W）、身高（L）和体表面积（BSA）的关系。
对61名健康志愿者（32名男性，年龄22.4±2.2岁）进行检查，体重70.9±12.2kg，身高1.78±0.09m，体表面积1.88±0.19m²。采用分段k空间屏气电影磁共振成像获取一组平行的短轴图像，通过逐层求和得出左心室容积和舒张末期质量。研究了四种不同的体型指数：W、L、L²和BSA。
在根据L、L²和BSA进行校正后，所有左心室参数的性别差异仍然存在。在根据W进行校正后，EDV和EDM的性别差异仍然存在，但SV和CO不再存在性别差异。对男性和女性分别进行了回归分析。男性和女性的EDV、SV、CO和EDM与每种体型指数均显著相关。一般来说，L或BSA比W更能预测左心室参数。EDV（ml）与L（m）的线性回归方程，男性为：EDV = 275×L - 359，女性为：EDV = 190×L - 215。SV（ml）与L的方程，男性为：SV = 186×L - 237，女性为：SV = 118×L - 121。左心室质量（g）与L的方程，男性为：质量 = 175×L - 179，女性为：质量 = 65.8×L - 10.9。
即使在根据体型指数进行校正后，左心室参数的大多数性别差异仍然存在。通过分别计算男性和女性的回归系数，给出了与体型指数相关的左心室参数正常参考值。这些正常值有助于为具有特定性别、体重和身高的患者获得更准确的参考值，从而改善正常和异常左心室参数之间的区分。
