Podojil M, Sedmera P, Vokoun J, Betina V, Baráthová H, Duracková Z, Horáková K, Nemec P
Folia Microbiol (Praha). 1978;23(6):438-43. doi: 10.1007/BF02885572.
Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities--echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by asperentin which had antibacterial and antifungal effects and, at a concentration of 86 microgram/ml, caused 50% mor7 tality in Artemia saline larvae. The highest cytotoxicity towards HeLa cells was found in physcion which caused 50% growth inhibition at a concentration of 0.1 microgram/ml.
在静态条件下培养的匐枝根霉菌丝体用于分离和鉴定代谢产物——棘球白素、大黄素、红青霉酸、黄青霉酸和曲霉亭；培养滤液产生了曲霉亭8-甲醚。曲霉亭具有最广泛的生物活性谱，具有抗菌和抗真菌作用，在浓度为86微克/毫升时，导致卤虫无节幼体50%的死亡率。对HeLa细胞毒性最高的是大黄素，在浓度为0.1微克/毫升时导致50%的生长抑制。
