Fox M R
Ann N Y Acad Sci. 1975 Sep 30;258:144-50. doi: 10.1111/j.1749-6632.1975.tb29274.x.
Toxicity of cadmium in the young Japanese quail rapidly produced moderate growth depression, hypogonadism in the male, decreased bone ash, severe anemia, alterations of "indicator" tissue levels of several essential inorganic elements, and marked histological abnormalities of the duodenum, bone marrow, adrenal medulla, and esophageal mucus glands. Cadmium appeared to have direct effects on zinc and iron, particularly iron (III), by decreasing intestinal absorption of these elements. Small amounts of dietary ascorbic acid were protective against many of the adverse effects of cadmium. The young quail proved to be a useful species for these studies. The experience with cadmium may have some facets that would prove useful in further studies of the effects of ascorbic acid on the toxicity of other metals.
镉对幼年日本鹌鹑的毒性会迅速导致生长适度减缓、雄性性腺功能减退、骨灰减少、严重贫血、几种必需无机元素的“指示”组织水平改变，以及十二指肠、骨髓、肾上腺髓质和食管黏液腺出现明显的组织学异常。镉似乎通过减少这些元素的肠道吸收，对锌和铁，尤其是铁（III）产生直接影响。少量膳食抗坏血酸可预防镉的许多不良反应。事实证明，幼年鹌鹑是进行这些研究的有用物种。镉的相关研究经验可能在进一步研究抗坏血酸对其他金属毒性的影响方面具有一定的借鉴作用。
