Sheu J H, Chang K C, Duh C Y
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.
J Nat Prod. 2000 Jan;63(1):149-51. doi: 10.1021/np9903954.
A new sterol, (22R,23R,24R)-5alpha,8alpha-epidioxy-22, 23-methylene-24-methylcholest-6-en-3beta-ol (1), as well as two known sterols, numersterol A (2) and pregnenolone (3), have been isolated from a soft coral Sinularia sp. The structure of metabolite 1 was determined by spectral analysis. Cytotoxicity of sterols 1-3 toward various cancer cell lines is also reported.
从一种软珊瑚中华柳珊瑚（Sinularia sp.）中分离出一种新的甾醇，即(22R,23R,24R)-5α,8α-环氧-22,23-亚甲基-24-甲基胆甾-6-烯-3β-醇（1），以及两种已知的甾醇，numersterol A（2）和孕烯醇酮（3）。代谢产物1的结构通过光谱分析确定。还报道了甾醇1-3对各种癌细胞系的细胞毒性。
