一种来自软珊瑚中华柳珊瑚属物种的具有细胞毒性的5α,8α-环氧甾醇。
A cytotoxic 5alpha,8alpha-epidioxysterol from a soft coral Sinularia species.
作者信息
Sheu J H, Chang K C, Duh C Y
机构信息
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.
出版信息
J Nat Prod. 2000 Jan;63(1):149-51. doi: 10.1021/np9903954.
PMID:10650100
Abstract
A new sterol, (22R,23R,24R)-5alpha,8alpha-epidioxy-22, 23-methylene-24-methylcholest-6-en-3beta-ol (1), as well as two known sterols, numersterol A (2) and pregnenolone (3), have been isolated from a soft coral Sinularia sp. The structure of metabolite 1 was determined by spectral analysis. Cytotoxicity of sterols 1-3 toward various cancer cell lines is also reported.
摘要
从一种软珊瑚中华柳珊瑚（Sinularia sp.）中分离出一种新的甾醇，即(22R,23R,24R)-5α,8α-环氧-22,23-亚甲基-24-甲基胆甾-6-烯-3β-醇（1），以及两种已知的甾醇，numersterol A（2）和孕烯醇酮（3）。代谢产物1的结构通过光谱分析确定。还报道了甾醇1-3对各种癌细胞系的细胞毒性。
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