一种表面抗原流感疫苗。2. 致热原性和抗原性。
A surface antigen influenza vaccine. 2. Pyrogenicity and antigenicity.
作者信息
Brady M I, Furminger I G
出版信息
J Hyg (Lond). 1976 Oct;77(2):173-80. doi: 10.1017/s0022172400024591.
Abstract
Conventional influenza vaccine containing whole virus particles purified on a zonal centrifuge is pyrogenic and can cause systemic and local adverse side effects. An improved vaccine was therefore prepared which contained only the surface antigens of the virus adsorbed to aluminium hydroxide. The antigenicity of this vaccine was compared with conventional vaccine in chickens. Both vaccines induced similar titres of serum haemagglutination-inhibition and neuraminidase inhibition antibody. The dose response curves, however, were different. The surface antigens at vaccine strength without aluminium hydroxide were of negligible pyrogenicity in rabbits.
摘要
通过区带离心法纯化的含全病毒颗粒的传统流感疫苗具有致热原性，可引起全身和局部不良反应。因此制备了一种改良疫苗，该疫苗仅含有吸附在氢氧化铝上的病毒表面抗原。在鸡身上比较了这种疫苗与传统疫苗的抗原性。两种疫苗诱导出的血清血凝抑制抗体和神经氨酸酶抑制抗体滴度相似。然而，剂量反应曲线不同。不含氢氧化铝的疫苗强度的表面抗原在兔身上的致热原性可忽略不计。
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