F1 杂交小鼠中亲本来源的 H-2 抗原表达的定量差异会影响 T 细胞反应。
Quantitative differences in the expression of parentally-derived H-2 antigens in F1 hybrid mice affect T-cell responses.
作者信息
O'Neill H C, Blanden R V
出版信息
J Exp Med. 1979 Mar 1;149(3):724-31. doi: 10.1084/jem.149.3.724.
Abstract
Quantitative absorption with specific anti-H-2 sera has shown that the H-2Kb and H-2Dd antigens coded by the B10.A(5R) haplotype are expressed in about fourfold lower amount on the spleen cells of [B10.A(5R) X B10.A(2R)]F1 hybrids than on parental B10.A(5R) cells. In contrast, the H-2Kk and H-2Db antigens of B10.A(2R) are expressed equally on parental and F1 cells. These quantitative differences are reflected in cytotoxic T-cell (Tc-cell) function. Macrophage target cells from F1 mice are killed less efficiently than B10.A(5R) targets by alloreactive or H-2 restricted Tc cells specific for H-2Kb or H-2Dd, and spleen cells of F1 mice are less efficient stimulators of alloreactive Tc cells specific for B10.A(5R) H-2 antigens, whereas F1 and B10.A(2R) cells are equal as targets and stimulators for Tc cells recognizing B10.A(2R) H-2 antigens.
摘要
用特异性抗H-2血清进行的定量吸收实验表明，由B10.A(5R)单倍型编码的H-2Kb和H-2Dd抗原，在[B10.A(5R)×B10.A(2R)]F1杂种小鼠的脾细胞上的表达量，比在亲代B10.A(5R)细胞上低约四倍。相反，B10.A(2R)的H-2Kk和H-2Db抗原在亲代细胞和F1细胞上的表达量相同。这些数量差异反映在细胞毒性T细胞（Tc细胞）功能上。F1小鼠的巨噬细胞靶细胞被针对H-2Kb或H-2Dd的同种反应性或H-2限制性Tc细胞杀死的效率低于B10.A(5R)靶细胞，并且F1小鼠的脾细胞作为针对B10.A(5R) H-2抗原的同种反应性Tc细胞的刺激物效率较低，而F1细胞和B10.A(2R)细胞作为识别B10.A(2R) H-2抗原的Tc细胞的靶细胞和刺激物是等效的。
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