Céspedes C L, Calderón J S, Lina L, Aranda E
Instituto de Química, Universidad Nacional Autónoma de Mexico, Ciudad Universitaria, 04510 Mexico D.F., Mexico.
J Agric Food Chem. 2000 May;48(5):1903-8. doi: 10.1021/jf990443q.
Dichloromethane extracts of Cedrela salvadorensis and Cedrela dugessi afforded a photogedunin epimeric mixture, gedunin and cedrelanolide. These compounds and the photogedunin epimeric acetates 3 and 4 at the 23-OH position were evaluated against Spodoptera frugiperda. Toosendanin, isolated from Melia azedarach, was used as a positive control. When tested for activity on neonate larvae into the no-choice bioassays, gedunin, photogedunin epimeric mixture, and photogedunin acetates mixture caused significant larval mortality with LC(50) of 39.0, 10.0, and 8.0 ppm at 7 days, respectively, as well as growth reduction. All the compounds tested inhibited larval growth, compared to the control, in a concentration-dependent manner. In addition, it was possible to observe significant reduced pupal weights and adult emergence. All the tested compounds except cedrelanolide showed comparable activity to that of toosendanin.
萨尔瓦多洋椿（Cedrela salvadorensis）和杜氏洋椿（Cedrela dugessi）的二氯甲烷提取物得到了一个光格杜宁差向异构体混合物、格杜宁和洋椿内酯。对这些化合物以及在23-羟基位置的光格杜宁差向异构体乙酸酯3和4针对草地贪夜蛾进行了评估。从苦楝（Melia azedarach）中分离得到的川楝素用作阳性对照。在针对初孵幼虫的无选择生物测定中测试活性时，格杜宁、光格杜宁差向异构体混合物以及光格杜宁乙酸酯混合物在7天时分别导致显著的幼虫死亡率，LC(50)分别为39.0、10.0和8.0 ppm，同时还抑制生长。与对照相比，所有测试的化合物均以浓度依赖的方式抑制幼虫生长。此外，还观察到蛹重显著降低以及成虫羽化率降低。除洋椿内酯外，所有测试的化合物均表现出与川楝素相当的活性。
