病毒性肺炎和细菌性肺炎对人体细胞介导免疫的影响。
Effect of viral and bacterial pneumonias on cell-mediated immunity in humans.
作者信息
Kauffman C A, Linnemann C C, Schiff G M, Phair J P
出版信息
Infect Immun. 1976 Jan;13(1):78-83. doi: 10.1128/iai.13.1.78-83.1976.
Abstract
Cell-mediated immunity (CMI) was assessed during infection and after convalescence in 12 patients with influenza pneumonia and 10 patients with bacterial pneumonia. The patients with influenza pneumonia had a marked impairment of skin test reactivity, and their lymphocytes showed a diminished response to phytohemagglutinin and streptokinase-streptodornase stimulation in vitro. Suppression of CMI was related to the severity of the pneumonia. Patients with bacterial pneumonia showed as great a suppression of the response to phytohemagglutinin and streptokinase-streptodornase as the patients with viral pneumonia. All parameters of CMI returned to normal in both groups after convalescence. The depression of CMI could not be related to a decrease in the number of thymus-derived lymphocytes or to serum-suppressive factors in these patients.
摘要
对12例流感肺炎患者和10例细菌性肺炎患者在感染期间及康复后进行了细胞介导免疫（CMI）评估。流感肺炎患者的皮肤试验反应性明显受损，其淋巴细胞对体外植物血凝素和链激酶-链道酶刺激的反应减弱。CMI的抑制与肺炎的严重程度相关。细菌性肺炎患者对植物血凝素和链激酶-链道酶的反应抑制程度与病毒性肺炎患者相同。两组患者康复后CMI的所有参数均恢复正常。这些患者CMI的降低与胸腺来源淋巴细胞数量的减少或血清抑制因子无关。
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