Saxena A, Phadke S R, Agarwal S S
Department of Medical Genetics, SGPGIMS, Lucknow.
Indian J Pediatr. 2000 Mar;67(3):225-30. doi: 10.1007/BF02723668.
Chronic diseases and malnutrition cause growth failure in childhood and adolescence. Correction of the cause of a growth deficiency is usually followed by catch-up growth. Capacity to catch-up is not only variable in different phases of growth, it is also different in different diseases and among different individuals suffering from the same disease. Catch-up growth is of three types. In type 1 catch-up growth, height deficit is swiftly eliminated after the growth restriction ceases. In type 2, after growth restriction ceases growth continues for longer than usual and growth arrest is compensated. Type 3 is a mixture of type 1 and type 2. Repeated episodes of growth inhibitory conditions result in lower catch-up rates in the subsequent periods. Although the exact mechanism regulating catch-up growth still remains a mystery, monitoring catch-up growth remains an important measure of the efficacy of the therapy and therefore of immense clinical importance.
慢性疾病和营养不良会导致儿童期和青春期生长发育迟缓。纠正生长发育不足的病因后通常会出现追赶生长。追赶生长的能力不仅在生长的不同阶段有所不同，在不同疾病以及患有相同疾病的不同个体之间也存在差异。追赶生长有三种类型。在1型追赶生长中，生长受限停止后身高缺陷迅速消除。在2型中，生长受限停止后生长持续时间比正常情况更长，生长停滞得到补偿。3型是1型和2型的混合。反复出现生长抑制情况会导致后续时期的追赶生长率降低。尽管调节追赶生长的确切机制仍是个谜，但监测追赶生长仍然是衡量治疗效果的一项重要指标，因此具有极其重要的临床意义。
