利用四亲代骨髓嵌合体的细胞实现组织不相容的T淋巴细胞和B淋巴细胞的协作。
Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.
作者信息
von Boehmer H, Hudson L, Sprent J
出版信息
J Exp Med. 1975 Oct 1;142(4):989-97. doi: 10.1084/jem.142.4.989.
Abstract
T-B collaboration has been studied in a secondary response to sheep erythrocytes using either syngeneic or allogeneic T- and B-cell combinations. T cells prepared from tetraparental bone marrow chimeras (TBMC), carrying H-2 determinants of one parental strain only, cooperated with syngeneic, as well as with allogeneic B cells carrying the alloantigens to which the T cells had been tolerized in the chimeric environment. When TBMC-derived cells of a single H-2 specificity were transferred with a mixture of TBMC-derived B cells of both H-2 types of the parental strains, no preference for syngeneic cooperation was found. The data therefore suggest that the presence of differing H-2-complex determinants on the allogeneic T- and B-cell populations of the two different strain combinations tested do not interfere with T-B collaboration when the cell populations studied are mutually tolerant.
摘要
在对绵羊红细胞的二次应答中，使用同基因或异基因T细胞与B细胞组合研究了T-B协作。从仅携带一个亲本品系H-2决定簇的四亲代骨髓嵌合体（TBMC）制备的T细胞，与同基因B细胞以及携带T细胞在嵌合环境中已耐受的同种异体抗原的异基因B细胞协作。当单一H-2特异性的TBMC来源细胞与来自亲本品系两种H-2类型的TBMC来源B细胞混合物一起转移时，未发现对同基因协作有偏好。因此，数据表明，在所测试的两种不同品系组合的异基因T细胞和B细胞群体上存在不同的H-2复合决定簇，当所研究的细胞群体相互耐受时，不会干扰T-B协作。
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Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.利用四亲代骨髓嵌合体的细胞实现组织不相容的T淋巴细胞和B淋巴细胞的协作。
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本文引用的文献
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Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
2
Cell-to-cell interaction in the immune response. VI. Contribution of thymus-derived cells and antibody-forming cell precursors to immunological memory.免疫反应中的细胞间相互作用。VI. 胸腺衍生细胞和抗体形成细胞前体对免疫记忆的作用。
J Exp Med. 1971 Jul 1;134(1):66-82. doi: 10.1084/jem.134.1.66.
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Genetic control of the immune response to (T,G)-A--L in C3H in equilibrium C57 tetraparental mice.C3H与处于平衡状态的C57四亲本小鼠中对（T，G）-A--L免疫反应的遗传控制。
Cell Immunol. 1974 Aug;13(2):264-77. doi: 10.1016/0008-8749(74)90244-5.
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A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
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Specific purification of lymphocyte populations on a digestible immunoabsorbent.在可消化免疫吸附剂上对淋巴细胞群体进行特异性纯化。
J Immunol. 1973 Jan;110(1):313-9.
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Cell interactions between histoincompatible T and B lymphocytes. VI. Cooperative responses between lymphocytes derived from mouse donor strains differing at genes in the S and D regions of the H-2 complex.组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。VI. 源自H-2复合体S区和D区基因不同的小鼠供体品系的淋巴细胞之间的协同反应。
J Exp Med. 1974 Jul 1;140(1):290-5. doi: 10.1084/jem.140.1.290.
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The separation of different cell classes from lymphoid organs. IX. A simple and rapid method for removal of damaged cells from lymphoid cell suspensions.从淋巴器官中分离不同细胞类别。IX. 从淋巴细胞悬液中去除受损细胞的一种简单快速方法。
J Immunol Methods. 1973 Apr;2(3):293-301. doi: 10.1016/0022-1759(73)90055-0.
8
Active suppression as a possible mechanism of tolerance in tetraparental mice.主动抑制作为四亲代小鼠耐受的一种可能机制。
J Exp Med. 1973 Feb 1;137(2):291-300. doi: 10.1084/jem.137.2.291.
9
Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice.C3H-CWB四亲本小鼠对聚-L（酪氨酸，谷氨酸）-聚-D，L-丙氨酸-聚-L-赖氨酸抗体反应的遗传控制。
J Exp Med. 1974 Dec 1;140(6):1660-75. doi: 10.1084/jem.140.6.1660.
10
Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。II. 来自同种异体供体品系的T淋巴细胞和B淋巴细胞在对半抗原-蛋白质结合物的体液反应中缺乏生理性协同相互作用。
J Exp Med. 1973 Jun 1;137(6):1405-18. doi: 10.1084/jem.137.6.1405.
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