迟发型超敏反应中的血浆因子。边缘性麻风反应中淋巴细胞反应的增强。
Plasma factors in delayed-type hypersensitivity. Augmentation of lymphocyte responses in borderline leprosy reactions.
作者信息
Bjune G, Barnetson R S
出版信息
Clin Exp Immunol. 1976 Dec;26(3):397-402.
The phytohaemagglutinin-induced responses of lymphocytes were found to be inhibited by plasma from patients with leprosy when compared with their responses in pooled serum from healthy donors. When patients developed reversal reactions, the initial inhibitory effect of their plasma was replaced by an augmentary effect on the responses to phytohaemagglutinin. The period of augmentation coincided with that of the reversal reaction in patients with borderline tuberculoid leprosy, but was delayed in patients with borderline lepromatous leprosy. The plasma from each leprosy patient was also observed to have the same effect on lymphocytes from unrelated individuals, showing that the inhibition and augmentation were due to factors in the plasma and not to a change in lymphocyte receptors. It is possible that the normal stable state of leprosy results from the presence of factors in plasma which act as a control mechanism, and that delayed hypersensitivity reactions may be caused by a breakdown of this control.
与来自健康供体的混合血清相比，发现麻风病患者的血浆可抑制淋巴细胞对植物血凝素的反应。当患者发生逆转反应时，其血浆最初的抑制作用被对植物血凝素反应的增强作用所取代。增强期与界线类偏结核样型麻风患者的逆转反应期一致，但在界线类偏瘤型麻风患者中延迟出现。还观察到，每位麻风病患者的血浆对无关个体的淋巴细胞具有相同作用，表明抑制和增强是由血浆中的因素引起的，而非淋巴细胞受体的变化。麻风病的正常稳定状态可能是由于血浆中存在作为控制机制的因素，而迟发型超敏反应可能是由于这种控制的破坏所致。
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