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Genetic-biochemical analysis and distribution of the Ambler class A beta-lactamase CME-2, responsible for extended-spectrum cephalosporin resistance in Chryseobacterium (Flavobacterium) meningosepticum.负责脑膜炎败血金黄杆菌（黄杆菌属）中对超广谱头孢菌素耐药的安布勒A类β-内酰胺酶CME-2的遗传生化分析及分布情况
Antimicrob Agents Chemother. 2000 Jan;44(1):1-9. doi: 10.1128/AAC.44.1.1-9.2000.
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OXA-type beta-lactamases.OXA型β-内酰胺酶
Curr Pharm Des. 1999 Nov;5(11):865-79.
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Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype typhimurium DT104 from French patients.来自法国患者的多重耐药鼠伤寒沙门氏菌血清型DT104分离株中整合子和羧苄青霉素酶介导的对阿莫西林-克拉维酸敏感性降低
Antimicrob Agents Chemother. 1999 May;43(5):1098-104. doi: 10.1128/AAC.43.5.1098.
4
Cloning, sequence analyses, expression, and distribution of ampC-ampR from Morganella morganii clinical isolates.摩根氏摩根菌临床分离株中AmpC - AmpR的克隆、序列分析、表达及分布
Antimicrob Agents Chemother. 1999 Apr;43(4):769-76. doi: 10.1128/AAC.43.4.769.
5
Molecular characterization of OXA-20, a novel class D beta-lactamase, and its integron from Pseudomonas aeruginosa.新型D类β-内酰胺酶OXA-20及其来自铜绿假单胞菌的整合子的分子特征
Antimicrob Agents Chemother. 1998 Aug;42(8):2074-83. doi: 10.1128/AAC.42.8.2074.
6
OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa.OXA-18，一种来自铜绿假单胞菌的D类克拉维酸抑制型超广谱β-内酰胺酶。
Antimicrob Agents Chemother. 1997 Oct;41(10):2188-95. doi: 10.1128/AAC.41.10.2188.
7
Comparison of biotyping, ribotyping, and pulsed-field gel electrophoresis for investigation of a common-source outbreak of Burkholderia pickettii bacteremia.生物分型、核糖体分型和脉冲场凝胶电泳用于调查皮氏伯克霍尔德菌菌血症共同来源暴发的比较
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8
Antibacterial activity of BMS-180680, a new catechol-containing monobactam.新型含儿茶酚单环β-内酰胺类抗生素BMS-180680的抗菌活性
Antimicrob Agents Chemother. 1997 May;41(5):1010-6. doi: 10.1128/AAC.41.5.1010.
9
Expression of the AsbA1, OXA-12, and AsbM1 beta-lactamases in Aeromonas jandaei AER 14 is coordinated by a two-component regulon.詹氏气单胞菌AER 14中AsbA1、OXA - 12和AsbM1β-内酰胺酶的表达由一个双组分调节子调控。
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10
Transfer of two Burkholderia and an Alcaligenes species to Ralstonia gen. Nov.: Proposal of Ralstonia pickettii (Ralston, Palleroni and Doudoroff 1973) comb. Nov., Ralstonia solanacearum (Smith 1896) comb. Nov. and Ralstonia eutropha (Davis 1969) comb. Nov.将两种伯克霍尔德菌属和一种产碱菌属细菌转移至罗尔斯通氏菌属新属：罗尔斯通氏菌皮氏亚种（Ralston、Palleroni和Doudoroff，1973年）新组合、罗尔斯通氏菌青枯亚种（Smith，1896年）新组合和罗尔斯通氏菌真养亚种（Davis，1969年）新组合的提议
Microbiol Immunol. 1995;39(11):897-904. doi: 10.1111/j.1348-0421.1995.tb03275.x.

来自皮氏罗尔斯通氏菌（假单胞菌属）的染色体诱导型D类β-内酰胺酶OXA-22的生化遗传学特征及分布

Biochemical-genetic characterization and distribution of OXA-22, a chromosomal and inducible class D beta-lactamase from Ralstonia (Pseudomonas) pickettii.

作者信息

Nordmann P, Poirel L, Kubina M, Casetta A, Naas T

机构信息

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France.

出版信息

Antimicrob Agents Chemother. 2000 Aug;44(8):2201-4. doi: 10.1128/AAC.44.8.2201-2204.2000.

DOI:10.1128/AAC.44.8.2201-2204.2000
PMID:10898703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC90041/
Abstract

From genomic DNA of Ralstonia pickettii isolate PIC-1, a beta-lactamase gene was cloned that encodes the oxacillinase OXA-22. It differs from known oxacillinases, being most closely related to OXA-9 (38% amino acid identity). The hydrolytic spectrum of OXA-22 is limited mostly to benzylpenicillin, cloxacillin, and restricted-spectrum cephalosporins. OXA-22-like genes were identified as single chromosomal copies in five other R. pickettii clinical isolates. The expression of OXA-22-like beta-lactamases was inducible in R. pickettii.

摘要

从皮氏罗尔斯通氏菌分离株PIC-1的基因组DNA中克隆到一个编码奥沙西林酶OXA-22的β-内酰胺酶基因。它与已知的奥沙西林酶不同，与OXA-9的关系最为密切（氨基酸同一性为38%）。OXA-22的水解谱主要限于苄青霉素、氯唑西林和窄谱头孢菌素。在其他5株皮氏罗尔斯通氏菌临床分离株中，OXA-22样基因被鉴定为单染色体拷贝。OXA-22样β-内酰胺酶在皮氏罗尔斯通氏菌中可诱导表达。