健康足月儿和早产儿血液白细胞对白假丝酵母菌的吞噬及杀伤能力
Phagocytosis and killing ability of Candida albicans by blood leucocytes of healthy term and preterm babies.
作者信息
Xanthou M, Valassi-Adam E, Kintsonidou E, Matsaniotis N
出版信息
Arch Dis Child. 1975 Jan;50(1):72-75. doi: 10.1136/adc.50.1.72.
The phagocytosis and killing ability of leucocytes of 24 term and 22 preterm babies against Candida albicans were studies during the first 20 days of life because of the increased incidence of monilia infection at this time. The leucocytes of 14 adults aged 20 to 30 years served as controls. The phagocytosis ability of the leucocytes in adults, term, and preterm babies was not significantly different, mean values being respectively 66-7%, 57%, and 56-9%. The killing ability of the leycocytes in term and preterm babies was lower when compared with that of adult leucocytes (P less than 0-001 for term and P less than 0-01 for preterm infants). The mean value in adults was 27-5%, in term infants 9-7%, and in preterm infants 9-5%. It is suggested that as the addition of adult serum did not improve the candidacidal ability of newborn leucocytes, the killing defect should be sought in the leucocyte itself and not in serum factors.
由于此时念珠菌感染的发生率增加，对24名足月儿和22名早产儿出生后20天内白细胞对白色念珠菌的吞噬和杀伤能力进行了研究。以14名年龄在20至30岁的成年人的白细胞作为对照。成年人、足月儿和早产儿白细胞的吞噬能力无显著差异，平均值分别为66 - 7%、57%和56 - 9%。与成年人白细胞相比，足月儿和早产儿白细胞的杀伤能力较低（足月儿P<0.001，早产儿P<0.01）。成年人的平均值为27 - 5%，足月儿为9 - 7%，早产儿为9 - 5%。由于添加成人血清并未提高新生儿白细胞的杀念珠菌能力，提示杀伤缺陷应在白细胞本身而非血清因子中寻找。
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